• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets >The Effect of Repeated Physical Exercise on Hippocampus and Brain Cortex in Stressed Rats
【24h】

The Effect of Repeated Physical Exercise on Hippocampus and Brain Cortex in Stressed Rats

机译：重复体育锻炼对应激大鼠海马和大脑皮层的影响

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sensitivity of target cells to glucocorticoids is regulated by the expression of intracellular glucocorticoid receptor (GR), which me diates the effects of glucocorticoids. The level of GR and of its nuclear transporter protein 70 (Hsp70) were followed in hippocampus and brain cortex of adult Wistar rat males exposed to acute (immobilization, cold) and chronic (social isolation, isolation, and 15 min daily swimming) stress or their combinations. Changes in plasma levels of adenocorti cotropic hormone and corticosterone were also studied. A significant decrease in cytosol GR and Hsp70 was observed after acute stress. Op posite to that, chronic stress led to negligible changes in both cytosol GR and Hsp70 levels. Isolation, as chronic psychosocial stressor, caused re duced responsiveness to novel acute stressors, judged by the cytosol GR and Hsp70 levels. This was not observed if chronic isolation was combined with 15 min daily swimming prior to acute exposure to immobilization. The data suggest that repeated physical exercise may, at least in some cases, diminish detrimental effects of chronic social isolation on limbic hypothalamic-pituitary-adrenocortical axis, as judged by the levels of GR and Hsp70 in the Wistar rat brain.
机译：靶细胞对糖皮质激素的敏感性受细胞内糖皮质激素受体（GR）表达的调节，该受体可调节糖皮质激素的作用。在成年Wistar大鼠雄性大鼠的海马和大脑皮层中，其GR水平及其核转运蛋白70（Hsp70）的水平受到急性（固定，寒冷）和慢性（社会隔离，隔离以及每天游泳15分钟）压力或他们的组合。还研究了血浆肾上腺皮质激素和皮质酮水平的变化。急性应激后观察到细胞质GR和Hsp70的显着降低。与此相反，慢性压力导致细胞质GR和Hsp70水平的变化可忽略不计。根据细胞溶质GR和Hsp70的水平，作为慢性心理社会应激源的隔离导致对新的急性应激源的反应性降低。如果在长期暴露于固定状态之前，将慢性隔离与每天15分钟的游泳相结合，则无法观察到这一点。数据表明，至少在某些情况下，通过Wistar大鼠大脑中GR和Hsp70的水平判断，重复进行体育锻炼至少在某些情况下可以减少慢性社会隔离对角膜下丘脑-垂体-肾上腺皮质轴的有害影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号