SRU Biosystems Inc. manufactures photonic crystal based biosensors, for drug discovery and diagnostic applications, in roll-to-roll format. Employing web based processing techniques results in advantageous consumable cost structure that enables new and important applications. For example, SRUs BIND label free sensor platform gives scientists engaged in drug discovery the means to screen for binding between candidate proteins, small molecules, or molecular fragments and target proteins or cell receptors without the use of conventional fluorescent or radioactive molecular tags (labels). Sub-wavelength periodicity in refractive index, typically across a planar surface, specifies the structure of a photonic crystal. Such a structure has allowed resonance modes defined sharply by the angle, wavelength, and polarization of incident light. An excited resonance mode yields high electromagnetic field strength confined closely to the plane of periodicity. The photonic crystal biosensor application takes advantage of the resonance condition, by localizing biochemical or cell based assay interactions within the high field region i.e. on the surface of the photonic crystal. SRU's sensor technology takes advantage of the interaction between the confined resonance field and assay material through two distinct sensing modes; label free detection and fluorescence amplification.
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