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首页> 外文会议>2007 IEEE/ICME INTERNATIONAL CONFERENCE ON COMPLEX MEDICAL ENGINEERING >Biodegradable Polylactide Microspheres Containing Anticancer Drugs Used as Injectable Drug Delivery System
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Biodegradable Polylactide Microspheres Containing Anticancer Drugs Used as Injectable Drug Delivery System

机译：含抗癌药的可生物降解的聚乳酸微球用作注射药物输送系统

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摘要

Biodegradable poly(lactic-acid) (PLA ) microspheres containing 5-fluorouracil were prepared by a solid in oil in water emulsion solvent evaporation method. The influences of various preparation parameters, such as polymer concentration, polymer molecular weight, oil-phase volume and PVA concentration in the external water phase on the characteristics of the microspheres and drug release profiles , the in vitro cell inhibition were investigated .It was found that the particle size was 100.25 ±2.50 μm and the drug loading was 8.25%(w/w). The in vitro release profiles of 5-fluorouracil loaded microspheres showed an initial burst release and thereafter the release was relatively slow. The in vitro cell inhibition indicate that the activity of 5-Fu is not weakened during the microshperes fabrication process and the solvent evaporation method is a mild fabrication technique for keeping drug stability.
机译：通过在水乳液溶剂蒸发法中的固体制备含有5-氟尿嘧啶的可生物降解的聚（乳酸）（PLA）微球。在外部水相中，各种制备参数的影响，例如聚合物浓度，聚合物分子量，油相体积和PVA浓度在微球和药物释放曲线的特征上，进行了体外细胞抑制。发现了体外细胞抑制作用粒径为100.25±2.50μm，药物负载为8.25％（w / w）。 5-氟尿嘧啶的微球的体外释放曲线显示出初始爆发释放，然后释放相对较慢。体外细胞抑制表明，在微型制造过程中，5-FU的活性不会削弱，并且溶剂蒸发方法是一种温和的制造技术，用于保持药物稳定性。

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