• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Ultrasonics Symposium (IUS), 2009 >Real-time ultrasound elasticity imaging for liver RF ablation assessment: Preliminary ex vivo and in vivo animal studies
【24h】

Real-time ultrasound elasticity imaging for liver RF ablation assessment: Preliminary ex vivo and in vivo animal studies

机译：用于肝脏射频消融评估的实时超声弹性成像：体外和体内动物初步研究

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this study, a real-time compression based ultrasound elasticity imaging prototype was developed and evaluated for liver radio-frequency ablation (RFA) assessment under ex vivo and in vivo conditions. The prototype was implemented on a commercial ultrasound system (iU22, Philips Healthcare) for an L12-5 linear transducer and a C5-1 curvilinear transducer. Under the ex vivo condition, two bovine liver samples were used for L12-5 and C5-1 respectively. Under the in vivo condition, a pig was anesthetized and mechanically ventilated. Ultrasound elasticity imaging experiments were performed during breath-hold in order to reduce respiratory motion artifacts. Post-RFA strain images were compared against several imaging modalities including MRI, contrast-enhanced CT and gross pathology. For the ex vivo case, a Rita Starburst probe (AngioDynamics, Queensbury, NY) was used to perform RFA and induce tissue deformation for strain imaging. Real-time strain images were generated pre- and post-RFA. After the ablation, the liver was imaged by a Panorama 1-T MRI system (Philips Healthcare), then it was dissected along the approximate ultrasound imaging plane for lesion dimension measurement using a caliper. The post-RFA strain images depicted an ablation zone with increased stiffness that was well correlated with the physiological changes observed in the T1-weighted MR image and gross pathology. For the second ex vivo liver sample, the strain image revealed an ablation zone of 4.90 cm ? 2.85 cm, and the MR image and gross pathology showed a zone of 4.56 cm ? 3.24 cm and of 4.91 cm ? 3.65 cm, respectively. For the in vivo study, three different commercial RFA needles were employed: the Covidien (Mansfield, MA) CoolTip single prong and triple-cluster probes, and the Rita Starburst probe. The animal underwent contrast-enhanced CT imaging immediately after RFA. It was then sacrificed and the ablated liver lobes were dissected for ex vivo MRI. All three imaging modalities showed compar-able measurement of lesion dimensions. The triple-cluster Covidien probe and the Rita probe with expanding tines seemed to perform better with elasticity assessment than the Covidien single prong probe. Preliminary results from this study demonstrate that real-time ultrasound strain imaging is potentially a valuable tool for assessing liver RFA. Further technical development of this prototype will advance toward real-time clinical use.
机译：在这项研究中，基于实时压缩的超声弹性成像原型被开发出来，并在离体和体内条件下进行了肝射频消融（RFA）评估。该原型在用于L12-5线性换能器和C5-1曲线换能器的商用超声系统（iU22，Philips Healthcare）上实现。在离体条件下，两个牛肝样品分别用于L12-5和C5-1。在体内条件下，将猪麻醉并进行机械通气。屏气过程中进行了超声弹性成像实验，以减少呼吸运动伪影。将RFA后的应变图像与包括MRI，对比增强CT和总体病理学在内的几种成像方式进行了比较。对于离体病例，使用Rita Starburst探针（AngioDynamics，纽约州昆斯伯里）进行RFA并诱导组织变形以进行应变成像。在RFA之前和之后生成实时应变图像。消融后，通过Panorama 1-T MRI系统（Philips Healthcare）对肝脏成像，然后沿着近似的超声成像平面解剖肝脏，以使用卡尺测量病灶尺寸。 RFA后的应变图像描绘了具有增加的刚度的消融区，该区与在T1加权MR图像和总体病理中观察到的生理变化高度相关。对于第二个离体肝脏样品，应变图像显示消融区为4.90 cm?。 2.85厘米，而MR图像和大体病理显示为4.56厘米？ 3.24厘米和4.91厘米？分别为3.65厘米。对于体内研究，使用了三种不同的商用RFA针头：Covidien（马萨诸塞州曼斯菲尔德）的CoolTip单叉和三簇探针，以及Rita Starburst探针。在RFA后立即对动物进行对比增强CT成像。然后将其处死并切下消融的肝叶用于离体MRI。所有这三种成像方式均显示出 能够测量病变尺寸。通过弹性评估，三簇式Covidien探针和带有扩展齿的Rita探针似乎比Covidien单叉探针表现更好。这项研究的初步结果表明，实时超声应变成像可能是评估肝脏RFA的有价值的工具。该原型的进一步技术开发将朝着实时临床应用的方向发展。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号