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首页> 外文会议>2009 WASE International Conference on Information Engineering(2009年国际信息工程会议)(ICIE 2009)论文集 >Study of the Relationship between Mus musculus Protein Sequences and their Biological Functions
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Study of the Relationship between Mus musculus Protein Sequences and their Biological Functions

机译：小家鼠蛋白质序列与其生物学功能关系的研究

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摘要

The central challenge in post-genomic era is to characterize the biological functions of newly discovered proteins. Sequence similarity based approaches infer protein functions based on the homology between proteins. We present the similarity relationship between protein sequences and their functions for mouse (Mus musculus) proteome in the context of gene ontology (GO) slim. The similarity between protein sequences is computed using a measure based on the BLAST alignment scores. The similarity between protein functions is characterized using GO terms. We present the sequence similarity distributions at different levels of the GO tree. The similarities of protein sequences in GO groups residing on different branches of the GO tree are shown. Our results indicate that proteins with similar ami no acid sequences tend to have similar biological functions. The posterior probabilities for correct function predictions were also computed. The result reveals certain limitations of the function prediction approaches that are solely based on sequence similarities.
机译：后基因组时代的主要挑战是表征新发现的蛋白质的生物学功能。基于序列相似性的方法基于蛋白质之间的同源性推断蛋白质功能。我们提出了在基因本体论（GO）苗条的背景下，蛋白质序列与它们对小鼠（小家鼠）蛋白质组的功能之间的相似性关系。使用基于BLAST比对得分的量度来计算蛋白质序列之间的相似性。蛋白质功能之间的相似性使用GO术语表征。我们介绍了GO树的不同级别上的序列相似性分布。显示了位于GO树的不同分支上的GO组中蛋白质序列的相似性。我们的结果表明，具有相似氨基酸序列的蛋白质往往具有相似的生物学功能。还计算了正确功能预测的后验概率。结果揭示了仅基于序列相似性的功能预测方法的某些局限性。

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