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THREE-DIMENSIONAL SIMULATIONS OF BLOOD FLOW WITH SYSTEMIC ARTERIAL BAROREFLEX

机译:全身动脉压力反射的血流三维模拟

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The systemic arterial baroreflex controls the systemic arterial pressure to maintain homeostasis. The carotid sinus and aortic arch are the major systemic arterial baroreceptors, and they respond to distention of the carotid and aortic walls causing compensatory mechanisms, which regulate heart rate, cardiac contractility, peripheral arterial resistance, venous compliance, and venous unstressed volume [1]. In this study, we connect a feedback control loop, which represents the systemic arterial baroreflex, to the closed loop system we developed in a previous study [2]. The three-dimensional finite element model of the aorta and the closed loop system enable us to obtain not only the physiologic flow rate and pressure fields of the finite element model but also the global characteristics of the cardiovascular system from the closed loop model. We study the autoregulatory mechanisms occurring due to the systemic arterial baroreflex by considering the interactions between the heart and the systemic and pulmonary circulations.
机译:全身动脉压力反射控制全身动脉压以维持体内平衡。颈动脉窦和主动脉弓是系统性的主要动脉压力感受器,它们对颈动脉和主动脉壁的扩张产生反应,从而引起补偿机制,这些机制调节心率,心脏收缩力,外周动脉阻力,静脉顺应性和静脉无压力[1] 。在这项研究中,我们将代表全身动脉压力反射的反馈控制回路连接到我们在先前研究中开发的闭环系统[2]。主动脉和闭环系统的三维有限元模型使我们不仅能够获得有限元模型的生理流速和压力场,而且还能从闭环模型中获得心血管系统的整体特征。我们通过考虑心脏与全身和肺循环之间的相互作用来研究由于全身动脉压力反射而发生的自调节机制。

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