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首页> 外文会议>ASME summer bioengineering conference;SBC2009 >ADENYLYL CYCLASE 6 MEDIATES PRIMARY CILIA-DEPENDENT CHANGES IN CYCLIC ADENOSINE MONOPHOSPHATE IN RESPONSE TO DYNAMIC FLUID FLOW
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ADENYLYL CYCLASE 6 MEDIATES PRIMARY CILIA-DEPENDENT CHANGES IN CYCLIC ADENOSINE MONOPHOSPHATE IN RESPONSE TO DYNAMIC FLUID FLOW

机译：腺苷酸环化酶6介导循环腺嘌呤单磷酸的初次依赖于唾液酸的变化，以响应动态流体流动

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It is well accepted that fluid flow is an important mechanical signal in regulating bone structure and function. Primary cilia, which are solitary, microtubule-based organelles that extend from the centrosome into extracellular space in many cell types, have been shown to mediate fluid flow-induced osteogenic responses in MLO-Y4 osteocyte-like cells [1], however, primary cilia did not mediate increases in intracellular Ca2+ concentration [1]. Recently, we identified cAMP as a novel early signaling molecule in primary cilia-dependent mechanotransduction of fluid flow in osteocytes. Specifically, we show that MLO-Y4 osteocyte-like cells respond to oscillatory flow with a rapid decrease in intracellular levels of cAMP that is dependent on the primary cilium [2]. Adenylyl cyclase 6 (AC6) is an enzyme responsible for the synthesis of cAMP from ATP. We found that AC 6 localizes to the primary cilium of bone cells (Fig. 1). In this study, our goal was to determine whether AC6 mediates the primary cilia-dependent, flow-induced decrease in cAMP.
机译：众所周知，流体流动是调节骨骼结构和功能的重要机械信号。原发纤毛是在许多细胞类型中从中心体延伸到细胞外空间的孤立的，基于微管的细胞器，已显示在MLO-Y4骨细胞样细胞中介导液流诱导的成骨反应[1]，但是，原发性纤毛纤毛没有介导细胞内Ca2 +浓度增加[1]。最近，我们确定cAMP作为骨细胞中纤毛依赖性纤毛依赖的机械转导中的一种新型早期信号分子。具体来说，我们显示MLO-Y4骨细胞样细胞响应振荡流，其细胞内cAMP水平迅速下降，而这取决于初级纤毛[2]。腺苷酸环化酶6（AC6）是负责从ATP合成cAMP的酶。我们发现AC 6定位于骨细胞的初级纤毛（图1）。在这项研究中，我们的目标是确定AC6是否介导了纤毛依赖性，血流诱导的cAMP降低。

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