• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>IMECE2008;ASME international mechanical engineering congress and exposition >Feasibility of Delivering a Novel Synthetic Membrane Anchor to the Deep Lungs
【24h】

Feasibility of Delivering a Novel Synthetic Membrane Anchor to the Deep Lungs

机译：向深肺提供新型合成膜锚的可行性

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Over recent years, respiratory drug delivery research has broadened to include a wide range of potential applications such as delivering drugs not only into the lung but across it. This includes both current and novel therapies. Comprehensive characterisation of drug delivery to the lungs is a complex task involving the determination of delivered and deposited dose. The main aim of this research is to study the feasibility of nebulising a new novel synthetic molecule that spontaneously and stably incorporate into the lipid bi-layers including cell membranes to a size suitable for delivery to the deep lungs. An electronic inverted microscope is used to view the particles nebulised by a jet nebulizer. A high speed video camera is mounted onto the microscope to view the magnified (400x) particles as they fly at 500 frames per second. Extensive image analysis and particle detection algorithms show that the new synthetic membrane anchor can be nebulised to an appropriate size (3 to 12 microns) and hence can be used as a carrier of target specific medication to the lungs. This may include the delivery of cancer, pulmonary disease and inhalation damage drugs to specific sites where treatment is required. The molecule could also be used for diagnostic purposes as a site specific marker for a particular disease in the lungs.
机译：近年来，呼吸药物输送研究已扩大到包括广泛的潜在应用，例如不仅将药物输送到肺中，而且将其输送到整个肺中。这包括当前和新颖的疗法。对肺部药物输送的全面表征是一项复杂的任务，涉及确定输送剂量和沉积剂量。这项研究的主要目的是研究雾化一种新的新型合成分子的可行性，该分子可以自发稳定地掺入脂质双层（包括细胞膜）中，并适合于输送至深肺。使用电子倒置显微镜观察由喷射雾化器雾化的颗粒。将高速摄像机安装在显微镜上，以观察放大的（400x）粒子，它们以每秒500帧的速度飞行。广泛的图像分析和颗粒检测算法表明，新的合成膜锚可以雾化到合适的大小（3到12微米），因此可以用作肺部靶向药物的载体。这可能包括将癌症，肺部疾病和吸入损害药物运送到需要治疗的特定部位。该分子还可以用于诊断目的，作为肺部特定疾病的位点特异性标记。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号