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首页> 外文会议>2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops >Immunomodulatory activity of herb-partition moxibustion on Stat3 and Stat4 in the mucosa of ulcerative colitis rats
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Immunomodulatory activity of herb-partition moxibustion on Stat3 and Stat4 in the mucosa of ulcerative colitis rats

机译：隔草灸对溃疡性结肠炎大鼠黏膜Stat3和Stat4的免疫调节活性

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摘要

A rat model of ulcerative colitis (UC) was established using an immunological method involving local stimulation. After the UC rat model was established, HPM was administered to the UC rats (n = 8) for seven days. UC rats without HPM (n = 8) and normal rats (n = 8) were used as the controls. Hematoxylin and eosin staining was used to visualize the pathological changes in the rats' colonic mucosa. The expression of Stat3 and Stat4 mRNAs in the colonic mucosa was detected with real-time fluorescent quantitative polymerase chain reaction. HPM ameliorated colonic mucosal damage in the UC model rats. HPM downregulated the expression of Stat4 mRNA in the colons of UC rats. HPM had no effect on the expression of Stat3 mRNA. HPM ameliorates the colonic mucosal damage in the UC rat model. Stat4 signaling is involved in the mechanism of HPM action.
机译：使用涉及局部刺激的免疫学方法建立溃疡性结肠炎（UC）大鼠模型。建立UC大鼠模型后，将HPM给予UC大鼠（n = 8），为期7天。使用无HPM的UC大鼠（n = 8）和正常大鼠（n = 8）作为对照。用苏木精和曙红染色观察大鼠结肠粘膜的病理变化。实时荧光定量聚合酶链反应检测结肠黏膜中Stat3和Stat4 mRNA的表达。 HPM改善了UC模型大鼠的结肠粘膜损伤。 HPM下调UC大鼠结肠中Stat4 mRNA的表达。 HPM对Stat3 mRNA的表达没有影响。 HPM改善了UC大鼠模型中的结肠粘膜损伤。 Stat4信号传导参与HPM的作用机制。

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