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首页> 外文会议>Proceedings of 2010 International Conference on Systems in Medicine and Biology >Correlating optical biopsy with histopathology of wounds under topical intervention with honey
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Correlating optical biopsy with histopathology of wounds under topical intervention with honey

机译：蜂蜜局部干预下光学活检与伤口组织病理学的相关性

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Non-invasive visualization of wound bed with depth information is important to understand the tissue repair under therapeutic interventions. In this context, present study performs skin swept source-optical coherence tomography (i.e. optical biopsy/OCT) and correlates findings with histo-pathological observations on different types of traumatic non-healing wounds under honey dressing. Correlation between OCT and microscopic observations were explored especially in respect to progressive growth and maturation of the epithelial and sub-epithelial components. Characteristic transition of uniform hypo-lucid band for de-pigmented zone to wavy highly lucid band for the pigmented zone in the OCT images could be directly correlated with the microscopic findings on transformation of flattened pre-mature epithelium of de-pigmented area to thicker and matured epithelium with rete-pegs in pigmented zone. This correlated evaluation of multimodal images demonstrates the applicability of SS-OCT in wound research and importance of integrated approach in validation of newer technology.
机译：具有深度信息的创面无创可视化对于了解治疗干预下的组织修复非常重要。在这种情况下，本研究进行了皮肤扫描源光学相干断层扫描（即光学活检/ OCT），并将发现与蜂蜜敷料下不同类型的创伤性非愈合伤口的组织病理学观察结果相关联。探索了OCT和显微镜观察之间的相关性，特别是在上皮和上皮下成分的逐渐生长和成熟方面。在OCT图像中，色素沉着区的均匀低透明条带向色素沉着区的波浪形高透明条带的特征转变可能与将色素沉着区的扁平早熟上皮转化为较厚和较薄的显微发现直接相关。成熟的上皮在色素区带有网状钉。这种对多峰图像的相关评估证明了SS-OCT在伤口研究中的适用性以及整合方法在验证新技术中的重要性。

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