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首页> 外文会议>Nanoelectronics Conference (INEC), 2010 >Label-free detection of glucose based on quantum dots
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Label-free detection of glucose based on quantum dots

机译：基于量子点的葡萄糖无标记检测

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A simple nanobiosensor based on CdTe/CdS quantum dots (QDs) was designed for the direct determination of glucose with high sensitivity. Herein we demonstrated that the photoluminescence (PL) of CdTe/CdS QDs was sensitive to hydrogen peroxide (H2O2). With glucose as substrate and glucose oxidase (GOx) as catalyzer, the product, H2O2 could quench the fluorescence of QDs. Experimental results showed that the decrease of fluorescent intensity was proportional to the concentration of glucose within the range of 1.8 ¿M-1 mM under the optimized experimental conditions. In addition, the detection was completed in 96-well plate as an original model of blood sugar detector. A good linear relationship was found within the range of 2 mM-30 mM. This QDs based sensor for glucose has the potential to be a portable blood sugar detector due to its high sample throughput, short assay time, low sample consumption and reduced overall cost.
机译：设计了一种基于CdTe / CdS量子点（QDs）的简单纳米生物传感器，用于高灵敏度直接测定葡萄糖。在本文中，我们证明了CdTe / CdS量子点的光致发光（PL）对过氧化氢（H 2 O 2 ）敏感。以葡萄糖为底物，葡萄糖氧化酶（GOx）为催化剂，产物H 2 O 2 可以猝灭量子点的荧光。实验结果表明，在优化的实验条件下，荧光强度的下降与葡萄糖浓度成正比，范围为1.8 µM-1 mM。另外，作为血糖检测器的原始模型，在96孔板中完成了检测。在2 mM-30 mM的范围内发现了良好的线性关系。这种基于QDs的葡萄糖传感器具有高样品通量，较短的分析时间，较低的样品消耗量和降低的总体成本，因此有可能成为便携式血糖检测仪。

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