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首页> 外文会议>2010 6th International Colloquium on Signal Processing and Its Applications >Potential neuroprotective effect of herbal extracts (NHA56) on hydrogen peroxide-induced SH-SY5Y cell lines
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Potential neuroprotective effect of herbal extracts (NHA56) on hydrogen peroxide-induced SH-SY5Y cell lines

机译：草药提取物（NHA56）对过氧化氢诱导的SH-SY5Y细胞系的潜在神经保护作用

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摘要

Oxidative stress has contributed a lot towards neurodegenerative diseases such as the Alzheimer''s and Parkinson''s diseases. One of the main factors of oxidative stress is reactive oxygen species (ROS). This research aimed to determine both the possible neurotoxic and neuroprotective effects of herbal extracts (designated as NHA56). This tablet-form medicine was claimed to be effective against muscle and joint pains and being commercialized without the certificate from Ministry of Health (KKM). In concern of that, this research was conducted, using SH-SY5Y cell lines induced with 100µM hydrogen peroxide. Ranges of herbal extracts concentrations between 100 ng/ml to 100 mg/ml were used to test for the neurotoxicity and neuroprotection of NHA56 herbal extracts. Results were determined using MTS Cell Proliferation Assay. Results obtained suggesting that NHA56 was not toxic to the cells and also possessed neuroprotective effect towards the hydrogen peroxide-induced neuronal cells. At concentration of 100 ng/ml, the herbal extracts showed the most significant effect of neuroprotective activity. Therefore, further research is the best for better understanding of the mechanisms behind its neuroprotective effect.
机译：氧化应激对诸如阿兹海默氏症和帕金森氏症等神经退行性疾病做出了很大贡献。氧化应激的主要因素之一是活性氧（ROS）。这项研究旨在确定草药提取物（指定为NHA56）的可能的神经毒性和神经保护作用。这种片剂形式的药物据称对肌肉和关节疼痛有效，并且没有获得卫生部（KKM）证书就可以商业化。考虑到这一点，这项研究是使用100μM过氧化氢诱导的SH-SY5Y细胞系进行的。浓度介于100 ng / ml至100 mg / ml之间的草药提取物用于测试NHA56草药提取物的神经毒性和神经保护作用。使用MTS细胞增殖测定法确定结果。获得的结果表明NHA56对细胞无毒，并且还具有对过氧化氢诱导的神经元细胞的神经保护作用。在100 ng / ml的浓度下，草药提取物表现出最显着的神经保护活性作用。因此，最好是进一步研究，以更好地了解其神经保护作用背后的机制。

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