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A Riemannian model of regional degeneration of the hippocampus in Alzheimer's disease

机译:阿尔茨海默氏病海马区域变性的黎曼模型

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We develop a Riemannian model of shape of solids in 3D space to map and compare localized hippocampal atrophy in normal aging, conversion to Alzheimer's disease (AD), and progression of the disorder over a 1-year period. The study is based on magnetic resonance scans of 428 subjects acquired 12 months apart by the Alzheimer's Disease Neuroimaging Initiative. Shape geodesics are used to model the spatiotemporal evolution of the anatomy of the hippocampus of each subject and to uncover regional differences in shape that are characteristic of the three dynamical processes. We identify regions where changes in shape due to neurodegeneration in conversion to AD differs significantly from normal aging suggesting potential morphological markers of incipient AD.
机译:我们在3D空间中建立了固体形状的黎曼模型,以绘制地图并比较正常衰老,转化为阿尔茨海默氏病(AD)和该疾病在1年期间的进展过程中的局部海马萎缩。这项研究是基于428位受试者的磁共振扫描,这些受试者相隔12个月才获得阿尔茨海默氏病神经影像学倡议。形状测地线用于对每个受试者海马体的解剖结构的时空演化进行建模,并揭示这三个动力学过程所特有的形状区域差异。我们确定了区域,其中由于向AD转化的神经退行性变而导致的形状变化与正常衰老显着不同,这提示了早期AD的潜在形态学标志。

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