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首页> 外文会议>Asia Pacific conference on biomechanics;International conference on biomedical engineering;ICBME;APBiomech;World congress of biomechanics;WCB 2010 >Development of Retinal Prosthesis Module for Fully Implantable Retinal Prosthesis
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Development of Retinal Prosthesis Module for Fully Implantable Retinal Prosthesis

机译：完全植入式视网膜假体的视网膜假体模块的开发

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To restore visual sensation of blind patients, we have proposed a fully implantable retinal prosthesis comprising an three dimensionally (3D) stacked retinal chip for transforming optical signal to electrical signal, a flexible cable with stimulus electrode array for stimulating retina cells, and coupling coils for power transmission. For realizing the fully implantable retinal prosthesis, we developed a key component of retinal prosthesis module comprising a retinal prosthesis chip and a flexible cable with stimulus electrode array. In this study, we used a 2D retinal chip as a prototype retinal prosthesis chip. We fabricated a polyimide-based flexible cable of 20μm thickness with 16 channels Pt stimulus electrode array. The retinal prosthesis chip was mounted on the flexible cable and encapsulated by a silicone to protect from corrosive environments in an eyeball. Then, the retinal prosthesis module was completely implanted into an eyeball of a rabbit. We successfully recorded the waveforms of electrically evoked potential (EEP) elicited from the rabbit brain by the current stimulation supplied from the implanted retinal prosthesis module for the first time. EEP amplitudes were proportionally increased according to illumination intensity and irradiation time of the incident light. It means that the rabbit would recognize the change of optical signal by changing the frequency of stimulus current pulse through the implanted retinal chip.
机译：为了恢复盲人的视觉，我们提出了一种完全可植入的视网膜假体，包括一个三维（3D）堆叠的视网膜芯片，用于将光信号转换为电信号;带有刺激电极阵列的柔性电缆，用于刺激视网膜细胞;以及耦合线圈。电力传输。为了实现完全可植入的视网膜假体，我们开发了视网膜假体模块的关键组件，该模块包括视网膜假体芯片和带有刺激电极阵列的柔性电缆。在这项研究中，我们使用2D视网膜芯片作为视网膜假体原型芯片。我们制作了厚度为20μm的具有16个通道的Pt刺激电极阵列的基于聚酰亚胺的柔性电缆。视网膜假体芯片安装在柔性电缆上，并用硅树脂封装，以防止眼球受到腐蚀。然后，将视网膜假体模块完全植​​入兔子的眼球中。我们成功地记录了首次从植入的视网膜假体模块提供的电流刺激从兔脑中诱发的电诱发电位（EEP）的波形。 EEP振幅根据照明强度和入射光的照射时间成比例地增加。这意味着兔子将通过改变通过植入的视网膜芯片的刺激电流脉冲的频率来识别光信号的变化。

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