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首页> 外文会议>2011 International Conference on Remote Sensing, Environment and Transportation Engineering >Association of Chinese medicine physiquein susceptibility to diabetic nephropathy and TGF-β 1 (T869C) gene polymorphism
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Association of Chinese medicine physiquein susceptibility to diabetic nephropathy and TGF-β 1 (T869C) gene polymorphism

机译：中药对糖尿病肾病的易感性与TGF-β1（T869C）基因多态性的关系

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Objective: To investigate influence of administration of Shenxiao decoction on the expression of NADPH oxidase, renal function and structure in diabetic nephropathy rat. Method: Experimental diabetic nephropathy model was induced by nephrectomy combined with streptozotocin (STZ) injection in sprague-dawley rat. Shenxiao decoction and Irbesartan were orally administrated respectively for 16 weeks, and the expression of NADPH oxidase subunit p22hox was measured. 24 h urine protein excretion (Upro) and renal pathological changes were observed. Results: The ratio of urinary protein excretion, the renal protein expression of p22phox were significantly increased in diabetic nephropathy rat, and the renal protein expression of Cu-Zn-SOD were significantly decreased in diabetic nephropathy rat.Shenxiao decoction and Irbesartan treatment can significantly prevent these changes in diabetic nephropathy rat. Conclusion: Shenxiao decoction treatment can significantly decrease the renal oxidative stress level, lessen the renal oxidative damage, and produce the protection of kidney in diabetic nephropathy rat.
机译：目的：探讨参消汤对糖尿病肾病大鼠NADPH氧化酶表达，肾功能和结构的影响。方法：采用肾切除联合链脲佐菌素（STZ）注射法制备大鼠糖尿病肾病模型。分别口服神消汤和厄贝沙坦16周，测定NADPH氧化酶亚基p22hox的表达。观察24 h尿蛋白排泄（Upro）和肾脏病理变化。结果：糖尿病肾病大鼠尿蛋白排泄率，p22phox肾蛋白表达明显升高，糖尿病肾病大鼠肾蛋白Cu-Zn-SOD表达明显降低，参消汤加厄贝沙坦治疗可明显预防这些改变在糖尿病性肾病大鼠中。结论：参消汤能明显降低糖尿病肾病大鼠的肾脏氧化应激水平，减轻肾脏氧化损伤，对肾脏具有保护作用。

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