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Tuning an activator-repressor clock employing retroactivity

机译:使用追溯调整激活器-抑制器时钟

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Activator-repressor systems have been shown to be capable of oscillations and are therefore an important clock motif in the field of Synthetic and Systems Biology. In this paper, we propose a method to regulate oscillatory behavior in such systems by the addition of DNA binding sites for the proteins involved in the clock network. We show that the retroactivity effect caused by this addition can effectively change the relative timescales among the protein dynamics and impact the behavior of the clock. We also employ root locus analysis to obtain a graphical interpretation of the results.
机译:活化抑制基因系统已被证明具有振荡能力,因此是合成和系统生物学领域的重要时钟主题。在本文中,我们提出了一种通过为时钟网络中涉及的蛋白质添加DNA结合位点来调节此类系统中振荡行为的方法。我们表明,由这种添加引起的追溯效应可以有效地改变蛋白质动力学之间的相对时标,并影响时钟的行为。我们还采用根轨迹分析来获得结果的图形解释。

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