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首页> 外文会议>2011 International Conference on Human Health and Biomedical Engineering >The changes of acid-sensing ion channel 1a in focal cerebral ischemic diabetes rats and neuroprotection of fasudil
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The changes of acid-sensing ion channel 1a in focal cerebral ischemic diabetes rats and neuroprotection of fasudil

机译：局灶性脑缺血糖尿病大鼠酸敏感离子通道1a的变化及法舒地尔的神经保护作用

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The symptoms of diabetes focal ischemia were more serious, but the concrete machanism is not very clear. For this we measure the expression of Acid — sensing ion channel 1a (ASIC1a) in ischemic cortex of diabetic rats during different time, meanwhile observe the protection of fasudil after ischemia. 72 male wistar rats were divided into 3 groups: focal ischemia, diabetes focal ischemia and fasudil interfere, ischemia 1h, 3h, 6h, 24h per group. high fat diet plus streptozotocin to model diabetic, thread cork to establish the models of focal ischemia. interfere group received 1mg/Kg fasudil injection by tail vein during half an hour after making diabetic model. The expressions of ASIC1a were detected by Western Blot. the results indicated diabetes groups were serious, ASIC1a were increasing and time-dependent (P<0.05); After fasudil, ASIC1a decreased significantly. So the aggravated cause of diabetes ischemia maybe associate with excessive opening of ASIC1a., Fasudil is neuroprotective by inhibit the expression of ASIC1a.
机译：糖尿病局灶性缺血的症状更为严重，但具体机制还不是很清楚。为此，我们测量了在不同时间糖尿病大鼠缺血皮层中的酸感应离子通道1a（ASIC1a）的表达，同时观察了法舒地尔对缺血后的保护作用。将72只雄性Wistar大鼠分为3组：局部缺血，糖尿病局部缺血和法舒地尔干预，每组缺血1h，3h，6h，24h。高脂饮食加链脲佐菌素模拟糖尿病，软木塞建立局灶性缺血模型。糖尿病模型制作后半小时，干预组尾静脉注射法舒地尔1mg / Kg。 Western Blot检测ASIC1a的表达。结果表明，糖尿病组严重，ASIC1a升高且呈时间依赖性（P <0.05）;法舒地尔治疗后，ASIC1a明显降低。因此，糖尿病缺血的加剧原因可能与ASIC1a的过度开放有关。法舒地尔通过抑制ASIC1a的表达而具有神经保护作用。

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