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首页> 外文会议>2011 International Conference on Human Health and Biomedical Engineering >Expression of PDGFR-β in colorectal cancer stroma and the relationship to lymphangiogenesis
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Expression of PDGFR-β in colorectal cancer stroma and the relationship to lymphangiogenesis

机译：PDGFR-β在大肠癌基质中的表达及其与淋巴管生成的关系

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Objective : To test the expression of PDGFR-β in colorectal cancer stroma, and evaluate the relationship to lymphangiogenesis. Methods: Applying Immunohistochemistry SP method, the expression of PDGFR-β in 90 patients with colorectal cancer and 20 normal tissues. Marked by D2–40, lymphatic microvessel density (LMVD) was counted. The expression of PDGFR-β and its relationship to LMVD and clinicopathologic factors was analyzed. Results: The expression of PDGFR-β was found significantly higher in colorectal cancer stroma than in normal tissues surrounding tumors[PDGFR-β: 46.67%(42/90) vs 20%(4/20), P<0.05]. The LMVD in cancer tissues was found significantly higher than in normal tissues surrounding tumors (P <0.05). Higher LMVD was found in groups with lymph node metastasis (26.06 + 16.41 vs 17.26 + 12.97, t =2.582, P <0.05). Also higher LMVD was found in colorectal cancer with positive PDGFR-β expression than with that corresponding negative expression [(27.63 + 15.46)vs (17.47 + 14.68), t =3.01, P <0.05]. High PDGFR-β expression was significantly more common with lymph node metastasis (P<0.05). Conclusion: The expression of PDGFR-β in colorectal cancer stroma was closely correlated with lymphangiogenesis and lymph node metastasis.
机译：目的：检测PDGFR-β在大肠癌基质中的表达，并探讨其与淋巴管生成的关系。方法：采用免疫组织化学SP法检测PDGFR-β在90例大肠癌及20例正常组织中的表达。以D2–40为标记，对淋巴微血管密度（LMVD）进行计数。分析PDGFR-β的表达及其与LMVD和临床病理因素的关系。结果：PDGFR-β在大肠癌基质中的表达明显高于肿瘤周围正常组织[PDGFR-β：46.67％（42/90）对20％（4/20），P <0.05]。发现癌组织中的LMVD明显高于肿瘤周围正常组织中的LMVD（P <0.05）。在淋巴结转移组中发现较高的LMVD（26.06 + 16.41对17.26 + 12.97，t = 2.582，P <0.05）。在PDGFR-β表达阳性的大肠癌中，LMVD也高于相应的阴性表达[（27.63 + 15.46）vs（17.47 + 14.68），t = 3.01，P <0.05]。 PDGFR-β高表达在淋巴结转移中更为常见（P <0.05）。结论：PDGFR-β在大肠癌基质中的表达与淋巴管生成和淋巴结转移密切相关。

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