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Analysis of the indications of empirical prescription in TCM based on association rules

机译：基于关联规则的中医经验方证指征分析

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Analyze the indications of empirical prescription and its relations in TCM, and provide a clear guide for the empirical prescription application. [Methods]: First, we collect the cases that professor Zhi-Min Yang uses the empirical prescription to remedy insomnia and investigate patient''s demographic feature, historical feature, four diagnostic techniques of TCM feature, Pittsburgh Sleep Quality Index(PSQI). Second, we observe the whole treatment, and define the standard of curative effect by PSQI reduced rate between before-treatment and post-treatment 1 month. Third, we divide the cases into invalid group and effective group by the standard of curative effect, and filter the preliminary features from effective group and invalid group by chi-square test. And then, analyze the relations among the preliminary indications by association rules (Apriori). [Results]: We had collected 40 cases. Base on the standard of curative effect, 28 of them had cured, 12 of them were invalid. We had investigated 206 features of each case, and filter 11 features from effective group and invalid group by chi-square test. Analyze the relations of among 11 preliminary indications by association rules. Extract 4 rules from invalid group (support 10%, confidence 80%) and 15 rules from effective group (support 60%, confidence 80%). [Conclusion]: The indications that professor Zhi-Min Yang remedy insomnia is follow the conditions: 1. Syndrome is yang or qi asthenia, its symptoms must contain one of the follow symptom: fatigue, afraid of cold, chilly, ice cold limbs. 2. Base on yang or qi asthenia syndrome, symptoms must merge “irascible” symptom. 3. Base on yang or qi asthenia, syndromes can''t merge “constipation” symptom.
机译：分析了中医经验处方的指征及其关系，为经验处方的应用提供了明确的指导。 [方法]：首先，我们收集杨志敏教授使用经验方剂来治疗失眠的病例，并调查患者的人口统计学特征，历史特征，中医特征的四种诊断技术，匹兹堡睡眠质量指数（PSQI）。其次，我们观察整个治疗过程，并定义治疗前和治疗后1个月之间PSQI降低率的疗效标准。第三，根据疗效标准将病例分为无效组和有效组，并通过卡方检验从有效组和无效组中筛选出初步特征。然后，通过关联规则（Apriori）分析初步指示之间的关系。 ［结果］：我们收集了40例病例。按照疗效标准，其中治愈28例，无效12例。我们调查了每种情况的206个特征，并通过卡方检验从有效组和无效组中过滤了11个特征。通过关联规则分析11个初步指征之间的关系。从无效组（支持10％，置信度80％）中提取4条规则，从有效组（支持60％，置信度80％）中提取15条规则。 [结论]：杨志敏教授治疗失眠的适应症有以下几种：1.综合症是阳虚或气虚，其症状必须包括以下症状之一：疲倦，怕冷，发冷，四肢冰冷。 2.基于阳虚气虚综合症，症状必须合并“易怒”症状。 3.以阳虚或气虚为基础的综合症不能合并“便秘”症状。

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