Systemic administration of drag-reducing polymers may be a novel and effective treatment for acute lung injury

机译：减阻聚合物的全身给药可能是急性肺损伤的一种新颖有效的治疗方法

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Over the past several decades, blood-soluble drag reducing polymers DRPs) have been shown to significantly enhance hemodynamics and improve hemorheology in various animal models when added to blood at nanomolar concentrations. Meanwhile, many more researchers appreciate that hemorheology abnormality underlies in acute lung injury (ALI) pathogenesis, especially in neutrophils extravasation mechanism. Therefore, we hypothesize that owing to DRPs' peculiarity to reduce microvascular resistance increase blood flow, and so on, systemic administration of DRPs may be a novel and effective treatment for ALI.

机译：在过去的几十年中，已证明当以纳摩尔浓度添加到血液中时，可溶于血液的减阻聚合物DRPs可显着增强各种动物模型的血流动力学并改善血液流变学。同时，更多的研究者意识到血液流变学异常是急性肺损伤（ALI）发病机制的基础，尤其是在中性粒细胞外渗机制中。因此，我们假设由于DRPs降低微血管阻力的特殊性增加了血流量，等等，全身性给药DRPs可能是ALI的一种新颖有效的治疗方法。

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《IT in Medicine and Education (ITME), 2011 International Symposium on》|2011年|p.414-416|共3页
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Zhao Shi-di; Li Yan;
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中图分类计算机的应用;
关键词
acute lung injury; drag-reducing polymers; hemorheology; microcirculation; neutrophils;

机译：急性肺损伤;减阻聚合物;血液流变学;微循环;中性粒细胞;

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Systemic administration of drag-reducing polymers may be a novel and effective treatment for acute lung injury

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