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Amorphous silicon based photodetectors for biosensing

机译:基于非晶硅的生物传感光电探测器

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Thin film photodiodes open interesting possibilities for enhancing well known optical detection methods in biosensing [1,2]. This contribution focuses on the development of a portable point-of-care (POCT) sensor system based on the direct optical and label-free detection of proteins by Reflectometric Interference Spectroscopy (RIfS) [3]. But more generally, the integration of amophous silicon (a-Si) based photodiodes into microfluidic sample handling environments enables miniaturization and parallelization of several optical techniques for biosensing, e.g. fluorescence labelling for DNA detection [4], chemiluminescence [5], or optical absorption [6] of appropriately labelled proteins.
机译:薄膜光电二极管为增强生物传感中众所周知的光学检测方法开辟了有趣的可能性[1,2]。该贡献集中于基于反射光谱干涉光谱法(RIfS)对蛋白质进行直接光学和无标记检测的便携式即时诊断(POCT)传感器系统的开发[3]。但更一般而言,将基于无定形硅(a-Si)的光电二极管集成到微流体样品处理环境中可实现多种光学技术的小型化和并行化,例如生物传感。用于适当检测的蛋白质的DNA检测[4],化学发光[5]或光吸收[6]的荧光标记。

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