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首页> 外文会议>2011 International symposium on innovations in intelligent systems and applications >Effects of channel blocking on the spontaneous firing regularity of scale-free Hodgkin-Huxley neuronal network
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Effects of channel blocking on the spontaneous firing regularity of scale-free Hodgkin-Huxley neuronal network

机译：通道阻塞对无鳞霍奇金-赫克斯利神经网络自发放电规律的影响

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摘要

The channel noise stemming from voltage-gated ion channels, which embedded in excitable neuronal membranes has a great impact on the production and propagation of the action potential in stochastic Hodgkin-Huxley (HH) neurons. In this study, we investigate the effects of sodium and potassium channels blockage and the average degree of connectivity on the spontaneous collective firing regularity on scale-free network which consisting of stochastic HH neurons. The obtained results reveal that potassium channel blockage has constructive effects on the firing regularity whereas sodium channel blockage has disruptive effects on the firing regularity. On the other hand, the spontaneous firing regularity exhibits coherence resonance depending on both the channel blockage scaling factor and the neuronal membrane area. The results also indicate that there is a lower boundary for the average degree of the network connectivity where the coherence resonance exists when the value of the network connectivity is greater than this lower boundary.
机译：来自电压门控离子通道的通道噪声嵌入到可兴奋的神经元膜中，对随机霍奇金-赫克斯利（HH）神经元中动作电位的产生和传播产生很大影响。在这项研究中，我们调查了钠和钾通道的阻塞以及平均连通性对无序网络中由随机HH神经元组成的自发集体放电规律的影响。获得的结果表明，钾通道的阻塞对射击规律具有建设性的影响，而钠通道的阻塞对射击规律具有破坏性的作用。另一方面，自发放电规律表现出相干共振，这取决于通道阻塞比例因子和神经元膜面积。结果还表明，当网络连接性的值大于该下限时，存在相干共振的网络连接的平均程度存在一个下限。

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