• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Academic Committee Conference of Shanghai key lab of stomatology >Aberrant Protein Expression and Promoter Methylation of p16 Gene Are Correlated With Malignant Transformation of Salivary Pleomorphic Adenoma
【24h】

Aberrant Protein Expression and Promoter Methylation of p16 Gene Are Correlated With Malignant Transformation of Salivary Pleomorphic Adenoma

机译：p16基因的异常蛋白表达和启动子甲基化与涎腺多形性腺瘤的恶性转化相关

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Context.—The significance of promoter methylation of the p16 gene and intracellular localization of p16 protein in the carcinogenesis of salivary carcinoma ex pleomorphic adenoma (Ca-ex-PA) is not clear. The correlation of the promoter methylation of the p16 gene and the expression and localization of p16 protein in Ca-ex-PA need to be further clarified. Objective.—To investigate the p16 protein expression and promoter methylation of p16 gene in Ca-ex-PA and their roles in the malignant transformation of pleomorphic adenoma to Ca-ex-PA. Design.—The p16 protein expression and promoter methylation of the p16gene were determined in both benign and malignant components of 50 primary salivary Ca-ex-PA tissues by immunohistochemistry and methylation-specific polymerase chain reaction. Expression of p16 protein and promoter methylation of the p16 gene between the benign and the malignant components was compared statistically.
机译：背景—在多形性腺瘤（Ca-ex-PA）涎腺癌的致癌作用中，p16基因的启动子甲基化和p16蛋白在细胞内定位的意义尚不清楚。在Ca-ex-PA中，p16基因的启动子甲基化与p16蛋白的表达和定位之间的关系有待进一步阐明。目的—研究Ca-ex-PA中p16蛋白的表达和p16基因的启动子甲基化及其在多形性腺瘤向Ca-ex-PA恶性转化中的作用。设计-通过免疫组织化学和甲基化特异性聚合酶链反应，在50例主要唾液Ca-ex-PA组织的良性和恶性成分中确定了p16基因的p16蛋白表达和启动子甲基化。统计比较良性和恶性成分之间的p16蛋白表达和p16基因启动子甲基化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号