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首页> 外文会议>Conference on photonic therapeutics and diagnostics VIII >Attenuation fluctuations and local dermal reflectivity are indicators of immune cell infiltrate and epidermal hyperplasia in skin inflammation
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Attenuation fluctuations and local dermal reflectivity are indicators of immune cell infiltrate and epidermal hyperplasia in skin inflammation

机译：衰减波动和局部皮肤反射率是皮肤炎症中免疫细胞浸润和表皮增生的指标

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Psoriasis is a common inflammatory skin disease resulting from genetic and environmental alterations of cutaneous immune responses responsible for skin homeostasis. While numerous therapeutic targets involved in the immunopathogenesis of psoriasis have been identified, the in vivo dynamics of psoriasis remains under investigated. To elucidate the spatial-temporal morphological evolution of psoriasis we undertook in vivo time course focus-tracked optical coherence tomography (OCT) imaging to non-invasively document dermal alterations due to immune cell infiltration and epidermal hyperplasia in an Imiquimod (IMQ) induced model of psoriasis-like inflammation in DBA2/C57B16 hybrid mice. Quantitative appraisal of dermal architectural changes was achieved through a three parameter fit of OCT axial scans in the dermis of the form A(z) = ρexp(—μz + ∈(z)). Ensemble averaging of the fit parameters over 2000 axial scans per mouse in each treatment arm revealed that the local dermal reflectivity p, decreased significantly in response to 6 day IMQ treatment (p = 0.0001), as did the standard deviation of the attenuation fluctuation std(e(z)), (p = 0.04), in comparison to cream controls and day 1 treatments. No significant changes were observed in the average dermal attenuation rate, μ. Our results suggest these label-free OCT-based metrics can be deployed to investigate new therapeutic targets in animal models as well as aid in clinical staging of psoriasis in conjunction with the psoriasis area and severity index.
机译：牛皮癣是一种常见的炎症性皮肤病，是由引起皮肤稳态的皮肤免疫反应的遗传和环境改变引起的。尽管已经确定了涉及牛皮癣免疫发病机理的许多治疗靶标，但是牛皮癣的体内动力学仍在研究中。为了阐明牛皮癣的时空形态演变，我们进行了体内时间过程焦点跟踪的光学相干断层扫描（OCT）成像，以非侵入性方式记录了由咪喹莫特（IMQ）诱导的模型中由于免疫细胞浸润和表皮增生引起的皮肤变化。 DBA2 / C57B16杂交小鼠的牛皮癣样炎症。真皮结构变化的定量评估是通过OCT轴向扫描在真皮中以A（z）=ρexp（-μz+∈（z））的三个参数拟合完成的。对每只治疗臂的每只小鼠进行2000次轴向扫描的拟合参数的集合平均值显示，响应6天IMQ处理后，局部皮肤反射率p显着降低（p = 0.0001），衰减波动std的标准偏差也是如此（ e（z）），（p = 0.04），与乳膏对照组和第1天治疗相比。平均皮肤衰减率μ没有观察到显着变化。我们的结果表明，这些基于无标签OCT的指标可用于研究动物模型中的新治疗靶标，并结合银屑病面积和严重程度指数来辅助银屑病的临床分期。

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