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首页> 外文会议>ASME summer bioengineering conference;SBC2012 >TRANSIENT TENSILE FACET CAPSULAR LIGAMENT LOADING ABOVE THE MECHANICAL THRESHOLD TO INDUCE PAIN ALSO REGULATES SPINAL NEURONAL HYPEREXCITABILITY
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TRANSIENT TENSILE FACET CAPSULAR LIGAMENT LOADING ABOVE THE MECHANICAL THRESHOLD TO INDUCE PAIN ALSO REGULATES SPINAL NEURONAL HYPEREXCITABILITY

机译：机械阈值之上的瞬时拉伸面囊状韧带负荷导致疼痛，也调节了脊柱神经过兴奋性

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摘要

Traumatic neck injuries are a primary cause of chronic pain, with the cervical facet joint and its capsule being a common source of the pain. During these injuries, the facet capsular ligament undergoes excessive stretching that can initiate pain [1]. Behavioral sensitivity is produced as early as 1 day after facet capsule stretch, which suggests that the excitatory systems in the spinal cord are modulated by certain tissue loading conditions. In particular, the signaling protein PKCs has been implicated in glutamate release in inflammatory pain [2] and is increased in afferents after painful facet injury [3]. Also, neuronal hyperexcitability has been detected after painful, but not nonpainful, facet joint distraction [4]. Despite the involvement of spinal neuronal activation in pain, the time course of its development and its relationship to painful mechanical facet joint injury is unknown.
机译：颈部外伤是造成慢性疼痛的主要原因，颈椎小关节及其囊膜是造成疼痛的常见原因。在这些损伤中，小囊囊韧带过度拉伸会引发疼痛[1]。行为敏感性最早在小平面囊拉伸后1天产生，这表明脊髓中的兴奋系统受到某些组织负荷条件的调节。特别是，信号蛋白PKCs参与了炎性疼痛中谷氨酸的释放[2]，疼痛小平面损伤后传入者中的谷氨酸盐释放增加[3]。同样，在疼痛但非疼痛的小关节分散之后，可以检测到神经元过度兴奋[4]。尽管脊髓神经元活化参与了疼痛，但其发展的时程及其与疼痛性机械性小关节损伤的关系尚不清楚。

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