首页> 外文会议>ASME summer bioengineering conference;SBC2012 >INVESTIGATING DIELECTROPHORETIC SIGNATURE OF MOUSE OVARIAN SURFACE EPITHELIAL CELLS, MACROPHAGES AND FIBROBLASTS
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INVESTIGATING DIELECTROPHORETIC SIGNATURE OF MOUSE OVARIAN SURFACE EPITHELIAL CELLS, MACROPHAGES AND FIBROBLASTS

机译:研究小鼠卵巢表面上皮细胞,巨噬细胞和成纤维细胞的介电信号

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Epithelial ovarian carcinomas are the fourth leading cause of death in women in the United States among all cancers and the leading cause of death from gynecological malignancies'. The main reason for this high rate of mortality is the inability to properly detect these carcinomas early. Investigations for diagnosing ovarian cancer in early stages have been hindered by two major obstacles: lack of adequate cell models to study different cancer stages and lack of a reliable technique to isolate these cancer cells from peritoneal fluid. In trying to solve the first challenge, Dr. Schmelz and collaborators presented a transformed mouse ovarian surface epithelial (MOSE) cell model by isolating different transitional stages of ovarian cancer as cells progressed from a premalignant nontumorigenic phenotype to a highly aggressive malignant phenotype.
机译:在所有癌症中,上皮性卵巢癌是美国女性的第四大死亡原因,也是妇科恶性肿瘤的主要死亡原因。如此高的死亡率的主要原因是无法正确地及早发现这些癌症。早期诊断卵巢癌的研究受到两个主要障碍的阻碍:缺乏足够的细胞模型来研究不同的癌症阶段以及缺乏可靠的技术将这些癌细胞从腹膜液中分离出来。为了解决第一个挑战,Schmelz博士和他的合作者提出了一种转化的小鼠卵巢表面上皮(MOSE)细胞模型,该方法通过分离卵巢癌从细胞癌变前的非致瘤性表型发展为高度侵袭性的恶性表型的不同过渡阶段来实现。

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