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Stroke unit of integrative medicine for post stroke comorbid anxiety and depression: A systematic review and meta-analysis of 25 randomized controlled trials

机译：中风后合并焦虑和抑郁的中西医结合卒中科：25项随机对照试验的系统评价和荟萃分析

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Objective: To review the effectiveness and safety of stroke unit of integrative medicine for post stroke comorbid anxiety and depression (PSCAD) systematically. Methods: Electronic databases of MEDLINE, Chinese Biomedical Literature Database, VIP Database, Wan-fang Database, CNKI Database were handled by computer retrieval, and Journal of Traditional Chinese Medicine were manually searched for papers of randomized controlled trial (RCT) on Chinese herbal medicine (CHM) plus pharmacotherapy versus pharmacotherapy in treating PSCAD. In accordance with the inclusion criteria, two reviewers independently screened the related literatures, assessed the risk of bias and extracted the literature data, while the software of RevMan5.2.6 was used for the combining data analysis. Results: A total of 25 studies involving 2,044 patients were identified for this review. Meta-analysis results indicated that the integrative group i.e. CHM plus pharmacotherapy group showed more effective for PSCAD (OR=3.63, 95%CI (2.67, 4.95)), lower HAMD (Hamilton depression scale) score (WMD=-3.84, 95%CI (-4.66, -3.02)), and less adverse events (OR=0.71, 95%CI (0.51, 0.97)) compared with the control group i.e. routine pharmacotherapy group. Conclusion: The meta-analysis indicated that the integrative medicine treatment could be more helpful in strengthening the clinical efficacy and reducing the incidence of adverse events in the treatment of PSCAD compared with routine pharmacotherapy. However, due to the small sample size of included trials and the relatively low-rating quality in the majority of studies, further large-scale, multi-center and rigorously-designed trials should be required to confirm the effectiveness and safety of integrative medicine for PSCAD.
机译：目的：系统评价中西医结合卒中治疗卒中后合并焦虑抑郁症的有效性和安全性。方法：通过计算机检索处理MEDLINE的电子数据库，中国生物医学文献数据库，VIP数据库，万方数据库，CNKI数据库，并手动搜索《中医药杂志》中草药的随机对照试验（RCT）论文（CHM）加上药物治疗与药物治疗来治疗PSCAD。根据纳入标准，两名审阅者独立筛选了相关文献，评估了偏倚风险并提取了文献数据，而使用RevMan5.2.6的软件进行了合并数据分析。结果：总共鉴定了25项研究，涉及2,044例患者。荟萃分析结果表明，CHM联合药物治疗组对PSCAD的疗效更好（OR = 3.63，95％CI（2.67，4.95）），HAMD（汉密尔顿抑郁量表）得分较低（WMD = -3.84，95％）与对照组（即常规药物治疗组）相比，CI（-4.66，-3.02）和更少的不良事件（OR = 0.71，95％CI（0.51，0.97））。结论：荟萃分析表明，与常规药物治疗相比，中西医结合治疗可更有效地增强PSCAD的临床疗效并减少不良事件的发生。但是，由于纳入研究的样本量较小且大多数研究的评分质量相对较低，因此应进一步进行大规模，多中心和严格设计的试验，以确认中西医结合药物的有效性和安全性。 PSCAD。

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