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首页> 外文会议>IEEE International Conference on Bioinformatics and Biomedicine >Modelling the role of spontaneous and collision induced catastrophe in the self organisation of cortical microtubules
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Modelling the role of spontaneous and collision induced catastrophe in the self organisation of cortical microtubules

机译：模拟自发和碰撞诱发的灾难在皮层微管的自组织中的作用

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Cortical microtubules form highly ordered structures through apparent self organisation. Two of the driving factors for this are believed to be the dynamic instability of the microtubules and the interactions that they have amongst themselves. In this paper we use a 3 state model to simulate the effect of the spontaneous growth to shrinkage rate and its relationship with the spontaneous shrinkage to growth rate. We find that the order of the microtubule is more sensitive to changes in the shrinkage to growth rate compared to its reverse. We also show that in microtubule collisions above the entrainment angle, in the absence of any other limiting factors, reducing the proportion of microtubules that undergo collision induced catastrophe (CIC) past 0.5 causes the array to rapidly lose order. This suggests that in cells with a low CIC, there exist additional mechanisms for controlling the microtubule growth direction.
机译：皮质微管通过明显的自组织形成高度有序的结构。人们认为，造成这种情况的两个驱动因素是微管的动态不稳定性以及它们之间的相互作用。在本文中，我们使用三态模型来模拟自发生长对收缩率的影响及其与自发收缩对生长率的关系。我们发现，微管的顺序与其收缩率相比，对收缩率至增长率的变化更为敏感。我们还表明，在夹带角以上的微管碰撞中，在没有任何其他限制因素的情况下，减少发生碰撞诱发的灾难（CIC）的微管比例超过0.5会导致阵列快速失去秩序。这表明在具有低CIC的细胞中，存在控制微管生长方向的其他机制。

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