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首页> 外文会议>IEEE Nuclear Science Symposium and Medical Imaging Conference >Evaluation of Monte Carlo-based compensation for scatter and crosstalk in simultaneous In-111/Tc-99m SPECT-CT imaging of infection
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Evaluation of Monte Carlo-based compensation for scatter and crosstalk in simultaneous In-111/Tc-99m SPECT-CT imaging of infection

机译：基于蒙特卡罗的散射和串扰评估在111 / TC-99M Spect-CT-CT-CT成像中的散射和串扰补偿

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Osteomyelitis (OM), a bone-marrow infection, is best diagnosed by simultaneous In-111 white blood cell and Tc-99m sulfur colloid imaging. The diagnosis has conventionally been based on a visual assessment of images, where a region of increased In-111 activity, spatially concordant with a region of decreased Tc-99m activity, indicates possible OM. To obtain more accurate and precise tomographic images of both radionuclides, we modified a previously developed Monte Carlo (MC)-based scatter and crosstalk estimation procedure based on a joint ordered-subsets expectation-maximization (MC-JOSEM) reconstruction algorithm, and compared its performance to that of a triple-energy-window-based (TEW-OSEM) reconstruction approach. A numerical phantom with eight simulated bone-marrow infection regions was used to evaluate the performance of both methods in simultaneous In-111/Tc-99m imaging. After using our SPECT MC program to simulate essentially noise-free data for both tracers, eight independent projections of Poisson-noise deviates were generated. Volumes of interest (VOI) were drawn in five normal-marrow and eight infected-marrow locations to assess the performance of both methods, with respect to that achievable using primary photons only from both nuclides. Overall, MC-JOSEM (χ2=1.7) outperformed TEW-OSEM (χ2=7.4). After one iteration, which provided the lowest mean-squared error of activity estimates, the average relative bias ± precision of reconstructed Tc-99m activity concentration in regions of infection decreased from 81.6±17.7% for images not compensated for scatter (NC) to 11.1±12.3% (MC) vs. 16.9±11.0% (TEW) and, in normal-bone regions, decreased from 34.4±22.5% (NC) to −3.9±10.8% (MC) vs. 4.1±11.5% (TEW). For In-111, the relative accuracy ± precision in regions of infection improved from 11.6±14.1% (NC) to 0.6±9.9 % (MC) vs. 15.5±- .5% (TEW) and, in normal-bone regions, decreased from 75.8±31.2% (NC) to 34.8±26.4% (MC) vs. 60.6±21.2% (TEW).
机译：骨髓炎（OM）是一种骨髓感染，最好通过同时In-111白细胞和TC-99M硫胶体成像最佳诊断。诊断常规基于对图像的视觉评估，其中111个活性增加的区域，随着TC-99M活性的区域的空间上交作，表明可能的OM。为了获得放射性核素的更准确和精确的断层摄影图像，我们根据关节订购的亚空预期 - 最大化（MC-JOSEM）重建算法，修改了先前开发的蒙特卡罗（MC）的散射和串扰估计程序，并比较了其基于三能级窗口（TEW-OSEM）重建方法的性能。使用八个模拟骨髓感染区的数值模型用于评估两种方法在111 / TC-99M成像中的性能。在使用我们的SPECT MC程序以模拟两个示踪剂的基本无噪声数据之后，产生了八个独立的泊松噪声偏离投影。利益卷（VOI）在五个正常骨髓和八个感染骨髓位置绘制，以评估两种方法的性能，相对于仅使用伯核苷酸的初级光子可实现的方法。总体而言，MC-JOSEM（χ 2 = 1.7）优于泰美术（χ 2 = 7.4）。在一次迭代之后，提供了活性估计的最低平均平均误差，感染区域中重建的TC-99M活性浓度的平均相对偏压±精度从81.6±17.7％降低，图像未被散射（NC）到11.1 ±12.3％（MC）与16.9±11.0％（TEW），在正常骨区中，从34.4±22.5％（NC）降至-3.9±10.8％（MC）与4.1±11.5％（泰国） 。对于111，感染区域中的相对精度±精度从11.6±14.1％（NC）改善为0.6±9.9％（MC）与15.5±0.5％（TEW），以及正常骨区，从75.8±31.2％（NC）降至34.8±26.4％（MC）与60.6±21.2％（TEW）。

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