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首页> 外文会议>Conference on Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics >A pilot study to compare the cerebral hemodynamics between patients with obstructive sleep apnea syndrome (OSA) and periodic limb movement syndrome (PLMS) during nocturnal sleep with near-infrared spectroscopy (NIRS)
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A pilot study to compare the cerebral hemodynamics between patients with obstructive sleep apnea syndrome (OSA) and periodic limb movement syndrome (PLMS) during nocturnal sleep with near-infrared spectroscopy (NIRS)

机译：通过近红外光谱（NIRS）比较夜间睡眠期间阻塞性睡眠呼吸暂停综合症（OSA）和周期性肢体运动综合症（PLMS）患者的脑血流动力学的初步研究

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摘要

Obstructive sleep apnea syndrome (OSA) and periodic limb movement in sleep syndrome (PLMS) are two common sleep disorders. Previous studies showed that OSA and PLMS share common features, such as increased cardio-vascular risk, both apnea events and limb movements occur periodically, they are usually associated with cortical arousals, and both of them can induce declines in peripheral oxygen saturation measured with pulse oximetry. However, the question whether apnea events and limb movements also show similar characteristics in cerebral hemodynamic and oxygenation has never been addressed. In this pilot study, we will first time compare the cerebral hemodynamic changes induced by apnea events and limb movements in patients with OSA (n=4) and PLMS (n=4) with NIRS. In patients with OSA, we found periodic oscillations in HbO_2, HHb, and blood volume induced by apnea/hypopnea events, HbO_2 and HHb showed reverse changing trends. By contrast, the periodic oscillations linked to limb movements were only found in HbO_2 and blood volume in patients with PLMS. These findings of different cerebral hemodynamics patterns between apnea events and limb movements may indicate different regulations of nervous system between these two sleep disorders.
机译：阻塞性睡眠呼吸暂停综合症（OSA）和周期性肢体运动性睡眠综合症（PLMS）是两种常见的睡眠障碍。先前的研究表明OSA和PLMS具有共同的特征，例如增加的心血管风险，呼吸暂停事件和肢体运动均周期性发生，它们通常与皮层唤醒有关，并且两者均可引起脉搏测量的外周血氧饱和度下降血氧饱和度。然而，呼吸暂停事件和肢体运动在脑血流动力学和氧合作用中是否也显示出相似的特征这一问题从未得到解决。在这项初步研究中，我们将首次比较OSA（n = 4）和PLMS（n = 4）伴NIRS的患者由呼吸暂停事件和肢体运动引起的脑血流动力学变化。在OSA患者中，我们发现呼吸暂停/呼吸不足事件引起的HbO_2，HHb和血容量周期性振荡，HbO_2和HHb呈反向变化趋势。相比之下，PLMS患者仅在HbO_2和血容量中发现与肢体运动有关的周期性振荡。在呼吸暂停事件和肢体运动之间不同的大脑血液动力学模式的这些发现可能表明这两种睡眠障碍之间神经系统的调节不同。

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