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首页> 外文会议>ASME bioengineering conference >CONTRIBUTION OF HEMODYNAMIC SHEAR STRESS MAGNITUDE AND FREQUENCY ABNORMALITIES TO CALCIFIC AORTIC VALVE DISEASE PATHOGENESIS
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CONTRIBUTION OF HEMODYNAMIC SHEAR STRESS MAGNITUDE AND FREQUENCY ABNORMALITIES TO CALCIFIC AORTIC VALVE DISEASE PATHOGENESIS

机译：血流动力学的剪切应力幅度和频率异常对钙化主动脉瓣疾病的致病性

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While the expression of pro-inflammatory cytokines BMP-4 and TGF-βl, ECM remodeling markers cathepsin L, and MMP-2 was upregulated under elevated FSS magnitude (at normal frequency) or elevated FSS frequency (at normal magnitude), it was either maintained or even downregulated in response to combined alterations in both FSS magnitude and frequency. Therefore, when combined, FSS magnitude and FSS frequency appear to have an attenuating effect on each other. This study demonstrates the sensitivity of valve leaflets to both WSS magnitude and pulsatility and the ability of supra-physiologic WSS magnitude or pulsatility to trigger events involved in early CAVD pathogenesis, which confirms our initial hypothesis that FSS alterations are key regulators of early CAVD progression.
机译：虽然促炎细胞因子BMP-4和TGF-β1，ECM重塑组织蛋白酶L和MMP-2的表达在FSS幅度升高（正常频率）或FSS频率升高（正常幅度）下被上调，但要么保持或什至下调，以响应FSS幅度和频率的综合变化。因此，当组合时，FSS幅度和FSS频率似乎对彼此具有衰减作用。这项研究证明了瓣叶对WSS幅度和脉动性的敏感性以及超生理性WSS幅度或脉动性触发与CAVD早期发病机制有关的事件的能力，这证实了我们最初的假设，即FSS改变是CAVD早期发展的关键调节因素。

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