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Focusing light within scattering media for photoacoustic tomography in a limited-view-angle tomography setting

机译:将光聚焦在散射介质中以在有限视角层析成像环境中进行光声层析成像

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In photoacoustic there is a trade-off between resolution and contrast at each depth, so it is difficult to accurately depict objects in deep regions. In recent years, scattering light control has been studied in various imaging fields. In this report, this control was applied to photoacoustic signals to increase the signal amplitude in the scatting media. To control the light, we used a feedback optical wavefront shaping technique and genetic algorithms (GAs) to optimize feedback. For the feedback signal, we use a photoacoustic signal in a transducer setting and a photoacoustic image in a limited-view-angle linear array probe setting. We demonstrated that wavefront light optimized by changing the light's speckle size can enhance the photoacoustic signal in tissue-mimicking phantoms in a confirmation experiment. We need to improve speed for biological imaging, but focusing light through scattering materials has potential in various biomedical applications.
机译:在光声中,每个深度的分辨率和对比度之间都需要权衡取舍,因此很难准确地描绘出较深区域中的物体。近年来,已经在各种成像领域中研究了散射光控制。在此报告中,此控件应用于光声信号,以增加散射介质中的信号幅度。为了控制光,我们使用了反馈光波前整形技术和遗传算法(GA)来优化反馈。对于反馈信号,我们在换能器设置中使用光声信号,在有限视角线性阵列探针设置中使用光声图像。我们通过确认实验证明,通过改变光的散斑大小而优化的波前光可以增强模拟组织的体模中的光声信号。我们需要提高生物成像的速度,但是通过散射材料聚焦光在各种生物医学应用中具有潜力。

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