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Comparison of ultrasound B-mode, strain imaging, Acoustic Radiation Force Impulse displacement and shear wave velocity imaging using real time clinical breast images

机译:超声B模式,应变成像,声学辐射力使用实时临床乳腺图像的声辐射力脉冲位移和剪切波速度成像

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It has been observed that many pathological process increase the elastic modulus of soft tissue compared to normal. In order to image tissue stiffness using ultrasound, a mechanical compression is applied to tissues of interest and local tissue deformation is measured. Based on the mechanical excitation, ultrasound stiffness imaging methods are classified as compression or strain imaging which is based on external compression and Acoustic Radiation Force Impulse (ARFI) imaging which is based on force generated by focused ultrasound. When ultrasound is focused on tissue, shear wave is generated in lateral direction and shear wave velocity is proportional to stiffness of tissues. The work presented in this paper investigates strain elastography and ARFI imaging in clinical cancer diagnostics using real time patient data. Ultrasound B-mode imaging, strain imaging, ARFI displacement and ARFI shear wave velocity imaging were conducted on 50 patients (31 Benign and 23 malignant categories) using Siemens S2000 machine. True modulus contrast values were calculated from the measured shear wave velocities. For ultrasound B-mode, ARFI displacement imaging and strain imaging, observed image contrast and Contrast to Noise Ratio were calculated for benign and malignant cancers. Observed contrast values were compared based on the true modulus contrast values calculated from shear wave velocity imaging. In addition to that, student unpaired t-test was conducted for all the four techniques and box plots are presented. Results show that, strain imaging is better for malignant cancers whereas ARFI imaging is superior than strain imaging and B-mode for benign lesions representations.
机译:已经观察到,与正常相比,许多病理过程增加了软组织的弹性模量。为了使用超声图像进行图像刚度,将机械压缩施加到感兴趣的组织和测量局部组织变形。基于机械激发,超声刚度成像方法被分类为压缩或应变成像,其基于外部压缩和声辐射力脉冲(ARFI)成像,其基于由聚焦超声波产生的力。当超声波聚焦在组织上时,横向产生剪切波,并且剪切波速度与组织的刚度成比例。本文提出的作品研究了使用实时患者数据在临床癌症诊断中进行菌株弹性造影和ARFI成像。使用Siemens S2000机器对50名患者进行超声波B模式成像,应变成像,ARFI位移和ARFI剪切波速度成像。根据测量的剪切波速度计算真正的模量对比度值。对于超声波模式,为良性和恶性癌症计算了ARFI位移成像和应变成像,观察到的图像对比度和与噪声比对比。基于由剪切波速度成像计算的真正模量对比度值进行比较观察到的对比度值。除此之外,还为所有四种技术进行了未配对的T检验,并提出了所有四种技术和箱子图。结果表明,对恶性癌症的应变成像更好,而ARFI成像优于应变成像和B型良性病变表示。

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