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Surface Engineered Pyrolyzed Carbon Electrode Arrays for Bio-sensing

机译:用于生物传感的表面工程热解碳电极阵列

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There is an urgent need to develop highly selective, sensitive and reproducible miniaturized bio-sensing platforms based on reliable interfaces is compatible with micro fabrication processing.. Our objective is to first create pyrolyzed carbon micropillar arrays with high surface area as bio-sensing electrodes, second to develop functionalization methods in order to improve the biomolecule immobilization efficiency and finally to understand the electrochemical phenomena occurring at the biomolecule/carbon interface. The carbon micropillar arrays with high aspect ratios and hierarchical porous surface have been fabricated by carbon microelectromechanical systems (C-MEMS). Nanomaterials have been integrated onto the micropillar arrays to further increase the accessible surface area and in order to achieve efficient covalent immobilization of biomolecules, various functionalization methods have been investigated. The developed bio-sensing platform was then applied to several applications including DNA sensors; H_2O_2 sensors, aptamer sensors and HIV sensors.
机译:基于与微加工工艺兼容的可靠接口,迫切需要开发高度选择性,灵敏且可重现的微型化生物传感平台。我们的目标是首先创建具有高表面积的热解碳微柱阵列作为生物传感电极,其次,开发功能化方法,以提高生物分子的固定效率,并最终了解在生物分子/碳界面处发生的电化学现象。已经通过碳微机电系统(C-MEMS)制造了具有高纵横比和分级多孔表面的碳微柱阵列。纳米材料已经整合到微柱阵列上,以进一步增加可及的表面积,并且为了实现生物分子的有效共价固定,已经研究了各种功能化方法。然后将开发的生物传感平台应用于DNA传感器等多种应用。 H_2O_2传感器,适体传感器和HIV传感器。

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