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首页> 外文会议>IEEE International Workshop on Artificial Immune Systems >EBVdb: a data mining system for knowledge discovery in Epstein-Barr virus with applications in T cell immunology and vaccinology
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EBVdb: a data mining system for knowledge discovery in Epstein-Barr virus with applications in T cell immunology and vaccinology

机译：EBVdb：用于在爱泼斯坦-巴尔病毒中发现知识的数据挖掘系统，并在T细胞免疫学和疫苗学中具有应用

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As the first cancer-causing human virus identified, Epstein-Barr virus (EBV) has been implicated in the development of a wide range of B cell lymphoproliferative disorders, a subset of T/NK cell lymphomas, and post-transplant lymphoproliferative disorders. We made use of the immunological data on EBV available through publications, technical reports, and databases and constructed Epstein-Barr virus T cell Antigen Database (EBVdb). EBVdb contains 2622 curated antigen entries of EBV antigenic proteins, 610 verified T cell epitopes and 26 verified HLA ligands. The data were subject to extensive quality control (redundancy elimination, error detection, and vocabulary consolidation). A set of computational tools for in-depth analysis, such as sequence comparison using BLAST search, multiple alignments of antigens, T cell epitope/HLA ligand visualization, T cell epitope/HLA ligand conservation analysis, and sequence variability analysis, have been integrated within the EBVdb. Predicted Class I and Class II HLA-binding peptides for 15 common HLA alleles are included in this database as putative targets. EBVdb seamlessly integrates curated data and information with tailored analysis tools to facilitate data mining for EBV vaccinology and immunology. EBVdb is a unique data source providing a comprehensive list of EBV antigens and peptides and is publicly available at http://projects.met-hilab.org/ebv/.
机译：作为确定的第一种致癌人类病毒，爱泼斯坦-巴尔病毒（EBV）与广泛的B细胞淋巴增生性疾病，T / NK细胞淋巴瘤的一部分以及移植后淋巴增生性疾病有关。我们利用了可通过出版物，技术报告和数据库获得的EBV免疫学数据，并构建了爱泼斯坦-巴尔病毒T细胞抗原数据库（EBVdb）。 EBVdb包含EBV抗原蛋白的2622个策展抗原条目，610个验证的T细胞表位和26个验证的HLA配体。数据受到广泛的质量控制（冗余消除，错误检测和词汇合并）。一组用于深度分析的计算工具已集成到其中，例如使用BLAST搜索的序列比较，抗原的多重比对，T细胞表位/ HLA配体可视化，T细胞表位/ HLA配体保守性分析和序列变异性分析。 EBVdb。该数据库中包含15种常见HLA等位基因的预测I类和II类HLA结合肽，作为推定目标。 EBVdb将经过整理的数据和信息与量身定制的分析工具无缝集成，以促进EBV疫苗学和免疫学的数据挖掘。 EBVdb是一个独特的数据源，提供了EBV抗原和肽的完整列表，可在http://projects.met-hilab.org/ebv/上公开获得。

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