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The Neurobiology of Executive Function Under Stress and Optimization of Performance

机译：压力下执行功能的神经生物学与性能优化

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Much basic and clinical research to date has investigated predictors of stress resilience and vulnerability, indicating, for example, that broad impact neurobiological factors, such as neuropeptide Y (NPY) and neuroactive steroids, are mechanistically related to short term stress resilience, as well as longterm patterns of stress-related medical and neuropsychiatric comorbidities. The problem is that we lack good methods for identifying predictors of stress resilience or vulnerability at an individual level, so that human performance and therapeutic interventions can be targeted precisely to underlying points of malfunction for maximum effectiveness. We thus propose modified experimental designs that capitalize on our growing capacities to query and analyze multimodal data across the translational levels of human biology and behavior. We propose that use of these methods in studies of individuals participating in intense military training or returning from deployment could enable better prediction of performance, and development of more effective personalized interventions aimed at optimizing and maintaining stress resilience over time.
机译：迄今为止，许多基础和临床研究都研究了压力弹性和脆弱性的预测因素，例如，表明广泛影响神经生物学因素，例如神经肽Y（NPY）和神经活性类固醇与短期压力弹性以及机理具有机械相关性。与压力有关的医学和神经精神病合并症的长期模式。问题在于，我们缺乏在个体水平上确定压力恢复力或脆弱性预测因素的好的方法，因此人类行为和治疗干预措施可以精确地针对潜在的故障点，以实现最大的有效性。因此，我们提出了经过修改的实验设计，以利用我们不断增长的能力来查询和分析人类生物学和行为的翻译水平上的多峰数据。我们建议在参加大量军事训练或从部署返回的个人的研究中使用这些方法可以更好地预测绩效，并开发出更有效的个性化干预措施，以期优化和保持压力适应能力。

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