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A simulation model of glucose-insulin metabolism and implementation on OSG

机译：葡萄糖-胰岛素代谢模拟模型及其在OSG上的实现

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摘要

In this paper, we present the design and implementation of a stand-alone tool for metabolic simulation and its deployment on the Open Science Grid (OSG). The case study model of glucose-insulin metabolism aims at the development of a real-time monitoring system that can assist patients with diabetes to handle their blood glucose profile and maintain healthy diet habit. This system is able to integrate custom-built SBML models along with users' food intake information and produces the estimation of ATP, Glucose, and Insulin for the given duration using numerical analysis and simulation. The tool has also been generalized to take into consideration of temporal genomic information and be flexible for simulation of any given biochemical models. After implementation on OSG, the results have demonstrated the effectiveness of numerical optimization for model selection and the feasibility of the proposed tool for the given metabolic simulation. The ATP-glucose and glucose-insulin correlations revealed by this tool can be promising for a variety of different application cases.
机译：在本文中，我们介绍了用于代谢模拟的独立工具的设计和实现及其在开放科学网格（OSG）上的部署。葡萄糖-胰岛素代谢的案例研究模型旨在开发一种实时监控系统，该系统可以帮助糖尿病患者处理其血糖状况并保持健康的饮食习惯。该系统能够将定制的SBML模型与用户的食物摄入信息集成在一起，并使用数值分析和模拟在给定的持续时间内生成ATP，葡萄糖和胰岛素的估算值。该工具也得到了普遍化，以考虑到时间基因组信息，并且可以灵活地模拟任何给定的生化模型。在OSG上实施后，结果证明了数值优化对模型选择的有效性，以及所提出的用于给定代谢模拟的工具的可行性。该工具揭示的ATP-葡萄糖和葡萄糖-胰岛素相关性在各种不同的应用案例中都有希望。

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