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Circadian Modulation of Sleep-Wake Dynamics Evaluated by Transition Probabilities

机译：过渡概率评估的睡眠-唤醒动力学的昼夜节律调制

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Behavioral states in rodents and other mammalian species alternate between wakefulness (WK), rapid eye movement (REM) and non-REM (NREM) sleep at time scale of hours (i.e., circadian and ultra-dian periodicties) and from several tens of minutes to seconds (i.e., brief awakenings during sleep). Quantified and statistical analysis of bout durations and transition probability analysis of sleep-wake dynamics constitute a powerful method for evaluating endogenous sleep control mechanisms and sleep disturbances. Here we studied the circadian influence over sleep-wake activity in mouse model by analyzing as a function of lightdark (LD) cycle, the Kaplan-Meier (KM) survival curves and the transition probability (TP) of Markov chains. Survival curves of WK showed a bimodal statistical distribution. Circadian rhythm modulated specifically WK bouts increasing its duration during activedark period. In contrast, NREM and REM KM curves did not change significantly along LD cycle. Circadian modulation of TP was found only for state-maintenance-probability in WK and for p_(WK—►NREM) transitions which increased and decreased respectively during activedark period. In conclusion, Markov modelling of sleep stages adequately evaluate the circadian and ultradian modulation of sleep-wake dynamics during dark and light phases.
机译：啮齿动物的行为状态和其他哺乳动物物种在清醒（WK）之间交替，快速眼球运动（REM）和非REM（NREM）在时间的时间（即昼夜昼夜和超级典范）和几十分钟开始秒（即睡眠期间的简短觉醒）。睡眠 - 唤醒动力学的呼出持续时间和过渡概率分析的量化和统计分析构成了评估内源性睡眠控制机制和睡眠障碍的强大方法。在这里，我们通过分析作为LightDark（LD）周期，Kaplan-Meier（KM）生存曲线和Markov链的过渡概率（TP）来研究鼠标模型中睡眠唤醒活动对鼠标模型的影响。 WK的存活曲线显示了双峰统计分布。昼夜节律调制特定的WK Bouts在Actiachard期间增加其持续时间。相比之下，NREM和REM KM曲线沿LD循环没有显着变化。仅针对WK中的状态维护概率和P_（WK-►NEREM）过渡时发现TP的昼夜昼夜调制仅在ACTIVARK期间分别增加和减少。总之，马尔可夫睡眠阶段建模充分评估昼夜光线和光相的睡眠 - 唤醒动力学的昼夜节目和超级调制。

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