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Initial Clinical Evaluation of Gated Stationary Digital Chest Tomosynthesis

机译：门控固定式胸部断层合成的初步临床评估

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High resolution imaging of the chest is dependent on a breath hold maintained throughout the imaging time. However, pediatric and comatose patients are unable to follow respiration commands. Gated tomosynthesis could offer a lower dose, high in-plane resolution imaging modality, but current systems are unable to prospectively gate in a reasonable scan time. In contrast, a carbon nanotube (CNT) based linear x-ray source array offers both the angular span and precise control necessary to generate x-ray projections for gated tomosynthesis. The goal of this study was to explore the first clinical use of the CNT linear x-ray source array for gated clinical chest imaging. Eighteen pediatric cystic fibrosis patients were recruited for this study, with 13 usable image sets. The s-GDCT system consists of a CNT linear x-ray source array coupled with a digital detector. A respiration signal derived from a respiratory belt served as a gating signal with sources fired sequentially when the imaging window and maximum inspiration window coincided. Images were reconstructed and reviewed for motion blur and ability to identify major anatomical structures. Image quality was highly dependent on quality of the respiration gating signal, and a correlation was found between qualitative image quality and height of the respiration peak. We demonstrate the first prospectively gated evaluation of the stationary digital chest tomosynthesis patients in pediatric patients. Though further refinements in projection selection and respiratory gating approaches are necessary, this study demonstrates the potential utility of this low dose imaging approach.
机译：胸部的高分辨率成像取决于整个成像时间内保持的屏气。但是，小儿和昏迷患者无法遵循呼吸指令。门控断层合成可以提供较低剂量，高面内分辨率的成像方式，但是当前系统无法在合理的扫描时间内进行前瞻性选通。相比之下，基于碳纳米管（CNT）的线性x射线源阵列既提供了角度跨度，又提供了生成用于门控断层合成的x射线投影所需的精确控制。这项研究的目的是探索CNT线性X射线源阵列在门控临床胸部成像中的首次临床应用。这项研究招募了18例小儿囊性纤维化患者，其中包括13个可用图像集。 s-GDCT系统由与数字检测器耦合的CNT线性X射线源阵列组成。当成像窗口和最大吸气窗口重合时，来自呼吸带的呼吸信号用作门控信号，并依次触发源。重建图像并进行运动模糊检查和识别主要解剖结构的能力。图像质量高度依赖于呼吸门控信号的质量，并且在定性图像质量和呼吸峰高度之间发现了相关性。我们展示了对儿科患者的固定式数字化胸部断层合成患者的首次前瞻性门控评估。尽管有必要在投影选择和呼吸门控方法上进一步完善，但这项研究证明了这种低剂量成像方法的潜在实用性。

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