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首页> 外文会议>Conference on Photonics in Dermatology and Plastic Surgery >Asymmetry in tissue oxygenation blood flow patterns between irradiated and contralateral breast tissues in relation to radiation dermatitis
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Asymmetry in tissue oxygenation blood flow patterns between irradiated and contralateral breast tissues in relation to radiation dermatitis

机译：在辐射皮炎中辐照和对侧乳腺组织之间的组织氧气血流模式的不对称性

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According to the American Cancer Society, it is projected that 1.8 million new cancer cases will arise. Of these new cases, 15% are expected to be Breast Cancer related. For many subjects undergoing radiation therapy (RT), radiation dermatitis (RD) is an unavoidable adverse reaction to necessary treatment. As much as 95% of RT subjects will experience RD during or after their treatment plan which can range from mild erythema to full necrosis of the treated tissue. Further complicating matters, the standard assessment approach for RD, the Common Terminology Criteria for Adverse Events (CTCAE), is subjective and relies on the treating clinician's visual assessment. Assessment of oxygenated blood flow changes holds potential as a means of assessing the severity of RD. In this study, spatial-temporal changes of tissue oxygenation, via a breath-hold paradigm, were monitored in breast cancer subjects across weeks of RT using a near infrared imaging approach. Subjects were imaged dynamically to acquire 2D spatial-temporal maps of tissue oxygenation. A Pearson's correlation-based approach was applied to spatial-temporal oxygenation maps to determine the extent of symmetry or asymmetry in oxygenated blood flow patterns. Current results indicate that the oxygenated blood flow in tissue regions neighboring the irradiated site are affected by radiation dermatitis. These results are significant as they infer that RT induces altered oxygenated blood flow that could potentially be correlated to RD severity, apart from static tissue oxygenation measurements.
机译：根据美国癌症社会，预计将出现180万新癌症病例。在这些新病例中，预计15％将是乳腺癌相关的。对于正在进行放射治疗（RT）的许多受试者，辐射皮炎（RD）是对必要治疗的不可避免的不良反应。高达95％的RT受试者将在治疗计划期间或之后经历RD，其可以从轻度红斑到治疗组织的全坏死。进一步复杂化问题，RD的标准评估方法，不良事件（CTCAE）的常见术语标准是主观的，是治疗临床医生的视觉评估。评估含氧血流变化具有评估RD严重程度的手段。在本研究中，使用近红外成像方法在RT的乳腺癌受试者中监测组织氧合的空间氧合的空间变化。受试者动态成像，以获取组织氧合的2D空间颞贴图。将Pearson的基于相关性的方法应用于空间 - 颞氧化图，以确定氧气血流模式中对称或不对称的程度。目前的结果表明，邻近辐照部位的组织区中的含氧血流受辐射皮炎的影响。这些结果显着，因为它们推断RT诱导改变的含氧血流，其可能与RD严重程度相关，除了静态组织氧合测量。

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