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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Aerosolization of silver nanoparticles during simulated use of a commercially available spray disinfectant product advertised to contain colloidal silver
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Aerosolization of silver nanoparticles during simulated use of a commercially available spray disinfectant product advertised to contain colloidal silver

机译：模拟使用市售的喷雾消毒剂产品时银纳米颗粒的气雾化，该产品宣称含有胶体银

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Silver nanoparticles (all three dimensions 1 -100 nm) are being exploited in diverse products such as spray surface cleaners used in homes and workplaces to take advantage of their potent antimicrobial properties. The use of these products may generate aerosols, and inhalation of silver nanoparticles causes chronic lung inflammation and liver abnormalities, cytotoxicity, and generation of reactive oxygen species in vitro and in vivo. Twenty-two products purported to contain silver were characterized to determine whether they actually contained silver and if it was present as nanoscale particles. One product, a sanitizer spray containing 6.1 mg/L of silver nanoparticles (mode = 20±13 nm by nanoparticle tracking analysis) was selected for testing in a 12.85 m3 chamber. Air was monitored using two aerodynamic particle sizers (range: <0.52 to 20 urn), one positioned near the spray bottle nozzle and the other 25 cm away near a tile surface. Aerosol was also collected onto filters for off-line analysis using scanning electron microscopy. Three different bottles of the spray product were tested. MPPD2 software was used to model respiratory deposition of aerosol. During spraying, aerosol concentration increased near the spray bottle nozzle (breathing zone) and near the tile surface. The geometric mean (GM) size and geometric standard deviation (GSD) of the aerosol droplets was 0.87 urn (167) and 1.03 um (1.79) at the nozzle and tile, respectively. Electron microscopy analysis identified nanoparticles in the dried aerosol droplets. Based on modeling for the breathing zone location, particle deposition fractions were 0.59,0.03, and 0.10 for the head, tracheobronchiolar, and alveolar regions, respectively. A commercially available antibacterial spray product released aerosol containing nanoparticles during simulated use. These particles have potential to deposit throughout the respiratory tract, including in the nasal passages, which could lead to translocation to other organs, including the brain.
机译：银纳米颗粒（所有三个维度均为1 -100 nm）正被用于多种产品中，例如用于家庭和工作场所的喷雾表面清洁剂，以利用其强大的抗菌性能。使用这些产品可能会产生气雾剂，吸入银纳米颗粒会导致慢性肺部炎症和肝脏异常，细胞毒性以及在体内和体外产生活性氧。对22个声称含银的产品进行了特征分析，以确定它们是否实际包含银以及是否以纳米级颗粒形式存在。选择一种产品，即含有6.1 mg / L的银纳米颗粒的消毒喷雾剂（通过纳米颗粒跟踪分析，模式= 20±13 nm），以便在12.85 m3的室内进行测试。使用两个空气动力学粒度仪（范围：<0.52至20）对空气进行监测，一个位于喷雾瓶喷嘴附近，另一个位于瓷砖表面25厘米处。还使用扫描电子显微镜将气溶胶收集到过滤器上以进行离线分析。测试了三种不同的喷雾产品瓶。 MPPD2软件用于模拟气溶胶的呼吸沉积。在喷涂过程中，喷雾瓶喷嘴（呼吸区）附近和瓷砖表面附近的气溶胶浓度增加。在喷嘴和瓷砖处，气溶胶液滴的几何平均（GM）大小和几何标准偏差（GSD）分别为0.87 ur（167）和1.03微米（1.79）。电子显微镜分析确定了干燥的气溶胶液滴中的纳米颗粒。根据呼吸区位置的模型，头部，气管支气管肺泡和肺泡区域的颗粒沉积分数分别为0.59、0.03和0.10。市售的抗菌喷雾产品在模拟使用过程中释放了包含纳米颗粒的气溶胶。这些颗粒有可能沉积在整个呼吸道中，包括在鼻道中沉积，这可能导致易位到包括大脑在内的其他器官。

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