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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Short-term temporal variability in urinary biomarkers of phosphate flame retardants and plasticizers (PFRs) and alternative plasticizers (APs)
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Short-term temporal variability in urinary biomarkers of phosphate flame retardants and plasticizers (PFRs) and alternative plasticizers (APs)

机译：磷酸盐阻燃剂和增塑剂（PFR）和替代增塑剂（AP）的尿液生物标志物的短期时间变异性

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Emerging chemicals such as phosphate flame retardants and plasticizers (PFRs) and alternative plasticizers (APs) have recently been introduced as replacements to more persistent chemicals and are therefore increasingly studied in human biomonitoring studies. Many of these chemicals have a shorter half-life than the ones they are replacing, which means that urinary metabolite concentrations likely only reflect short-term exposure. However, it is not clear whether biomarkers levels of these chemicals are stable or fluctuating over time. This is of critical importance for biomonitoring studies that generally use only one spot urine sample per participant. We aimed to investigate the intra- and inter-day variability of PFR and AP metabolite concentrations over a 5-day period and to compare the reliability of spot urine samples versus 24 hours urine to predict general exposure. In this study, ten healthy volunteers of at least 18 years old provided every urine sample they produced for 5 consecutive days, followed by one day of 24-hour urine collection. PFR and AP metabolite concentrations were quantified by validated analytical protocols based on solid-phase extraction (SPE) and liquid-chromatography tandem mass-spectrometry (LC-MS/MS). Spearman's rank correlation was used to relate metabolite concentrations. Intraclass correlation coefficients were calculated to assess temporal variability. Of the 14 PFR metabolites measured, eight were found in more than half of the samples. Of the 11 AP metabolites measured, five had a detection frequency above 50%. Median concentrations were comparable to the levels reported in our pilot studies. Moderate to strong correlations were observed between metabolites coming from the same parent compound. Intra class coefficients were of moderate strength for the majority of the investigated compounds (i.e. 0.4 - 0.6), however some metabolites had much higher values (>0.6) which showed that these concentrations varied little across time. Correlation strength did not improve significantly after adjustment for SG or Cr.
机译：近年来，新兴的化学品，例如磷酸盐阻燃剂和增塑剂（PFR）和替代性增塑剂（APs）被引入，以替代更具持久性的化学品，因此在人体生物监测研究中得到了越来越多的研究。这些化学药品中的许多化学药品的半衰期比其要替换的化学药品的半衰期短，这意味着尿中代谢物的浓度可能仅反映了短期接触。但是，尚不清楚这些化学物质的生物标志物水平是否稳定或随时间波动。这对于通常每个参与者仅使用一个尿样的生物监测研究至关重要。我们的目的是调查5天内PFR和AP代谢产物浓度的日内和日间变化，并比较点尿样品和24小时尿液的可靠性，以预测一般暴露量。在这项研究中，十名至少18岁的健康志愿者连续5天提供他们产生的每份尿液样本，然后一天进行24小时尿液收集。通过基于固相萃取（SPE）和液相色谱串联质谱（LC-MS / MS）的有效分析方案对PFR和AP代谢物浓度进行定量。 Spearman等级相关性用于关联代谢物浓度。计算类内相关系数以评估时间变异性。在测量的14种PFR代谢产物中，超过一半的样品中发现8种。在所测量的11种AP代谢物中，有5种的检测频率高于50％。中位数浓度与我们的先导研究报告的水平相当。在同一母体化合物的代谢产物之间观察到中等至强相关性。对于大多数所研究的化合物，类内系数的强度中等（即0.4-0.6），但是某些代谢物的值更高（> 0.6），这表明这些浓度随时间变化很小。调整SG或Cr后，相关强度没有显着提高。

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