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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Long-lasting Legacies: Organochlorine Compounds in Children and Adolescents - Results of the German Environmental Survey, GerES 2014-2017
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Long-lasting Legacies: Organochlorine Compounds in Children and Adolescents - Results of the German Environmental Survey, GerES 2014-2017

机译：持久遗产：儿童和青少年中的有机氯化合物-德国环境调查的结果，GerES 2014-2017

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Background and Methods: A number of organochlorine compounds (OC) have been strictly regulated in Germany already decades ago. For providing data on the current internal exposure of children and adolescents (3 to 17 years), OC were investigated in the German Environmental Survey (GerES V) carried out from 2014 to 2017. GerES V was jointly performed with Wave 2 of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS W2) of the Robert Koch Institute (RKI). Among other OC, dichlorodiphenyldichloroethylene (DDE, dichlorodiphenyltrichloroethane (DDT) metabolite) and polychlorinated biphenyls (PCB118, PCB153, and PCB180) were quantified in 1,135 blood plasma samples by GC-MS/MS. Sociodemographics and data on health-relevant behaviors were used in statistical analyses. Results: The overall geometric mean (GM) concentration of DDE was 0.158 pg/L. GMs increased with socioeconomic status and migrational background. For the sum of the three higher-chlorinated PCBs (PCB-Sum) GM was 0.303 pg/L with higher GMs in males. PCB-Sum GMs increased with socio-economic status but decreased with migrational background. DDE and PCB-Sum was higher in former East and West Germany, respectively. For both parameters, GM where higher in participants that had been breastfed. Discussion: Decades after national regulation and being included in the Stockholm Convention of 2004, health-relevant OC are today still ubiquitous in Germany's population. Current regional internal exposure differences can be explained by the country's separation until 1990 with different OC usage patterns. GerES V yields detailed information on sources and routes that can explain current difference between sub-populations and support further exposure reduction. Moreover, the study data provides sound empirical evidence of the long-lasting impact of persistent chemicals. Acknowledgements: We thank all participants and the RKI for making GerES V possible. Funding by the German Ministries for the Environment, Nature Conservation and Nuclear Safety (BMU) and of Education and Research (BMBF) is gratefully acknowledged.
机译：背景和方法：几十年前，德国已经对许多有机氯化合物（OC）进行了严格管制。为了提供有关当前儿童和青少年（3至17岁）内部暴露的数据，在2014年至2017年进行的德国环境调查（GerES V）中对OC进行了调查。GerES V与德国卫生部第二次浪潮联合进行罗伯特·科赫研究所（RKI）的儿童和青少年访谈和考试调查（KiGGS W2）。在其他OC中，通过GC-MS / MS对1,135个血浆样品中的二氯二苯基二氯乙烯（DDE，二氯二苯基三氯乙烷（DDT）代谢产物）和多氯联苯（PCB118，PCB153和PCB180）进行了定量。在统计分析中使用了社会人口统计学和有关健康相关行为的数据。结果：DDE的总体几何平均（GM）浓度为0.158 pg / L。随着社会经济地位和移民背景，转基因数量增加。对于三种高氯多氯联苯的总和（PCB-Sum），GM为0.303 pg / L，其中男性的GM较高。 PCB-Sum GMs随着社会经济地位的增加而增加，但随着移民背景的增加而下降。前东德和西德的DDE和PCB-Sum分别较高。对于这两个参数，使用母乳喂养的参与者的GM较高。讨论：与国家法规相距数十年并被纳入2004年《斯德哥尔摩公约》的与健康相关的OC今天在德国人口中仍然无处不在。当前区域内部暴露的差异可以用该国在1990年之前的分离以及不同的OC使用模式来解释。 GerES V提供了有关来源和路线的详细信息，可以解释亚种群之间的当前差异并支持进一步减少暴露。此外，研究数据提供了持久性化学品长期影响的可靠经验证据。致谢：感谢所有参与者和RKI使GerES V成为可能。非常感谢德国环境，自然保护和核安全部（BMU）和教育与研究部（BMBF）的资助。

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