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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Air pollution is associated with Pediatric Emergency Room admissions for bronchiolitis
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Air pollution is associated with Pediatric Emergency Room admissions for bronchiolitis

机译：空气污染与小儿急诊室毛细支气管炎的入院有关

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Background: in the last decade air pollution has been linked to an increased risk of several respiratory diseases in children, in particular respiratory tract infections. The present study aimed to evaluate the association between Pediatric Emergency Room (PER) admissions for bronchiolitis and air pollution. Methods: PER admissions due to bronchiolitis in children aged less than 1 year were retrospectively collected from 2007 to 2018 in Padua, Italy. Daily environmental data were obtained from monitoring stations located within 30 km from the children residence. A conditional logistic regression based on a time-stratified case-crossover design was performed to evaluate the association between PER admissions and exposure to nitrogen dioxide (NO2), particulate matter of less than 2.5 u.m (PM2.5) and less than 10 um (PM10) in aerodynamic diameter. Models were adjusted for atmospheric pressure, temperature, humidity and national holidays. Odds Ratio for lags from 0 to 15 and the average of the 7 days before the access (Iag07) were obtained. A secondary analysis was focused only on children that were hospitalized. Results: 2333 children presented to the PER for bronchiolitis. An association was found on lag 0, lag 1, lag 3 and Iag07 with both PM2.5 and PM10. Considering only children with a more severe outcome that led to hospitalization, the association was statistically significant until lag 5 and on Iag07. Major effects of NO2 on PER admission and hospitalization were found from lag 5 to lag 13. Conclusion: PM and NO2 are associated with PER admissions for bronchiolitis. Exposure of infants to air pollution could damage the respiratory tract mucosa facilitating viral infections and exacerbating symptoms.
机译：背景：在过去的十年中，空气污染与儿童患多种呼吸道疾病（尤其是呼吸道感染）的风险增加有关。本研究旨在评估细支气管炎的儿科急诊室（PER）入院与空气污染之间的关联。方法：回顾性收集2007年至2018年意大利帕多瓦（Padua）的1岁以下儿童因毛细支气管炎引起的PER入院信息。每天的环境数据是从距离儿童住所30公里以内的监测站获得的。进行了基于时间分层病例交叉设计的条件逻辑回归，以评估PER摄入量与暴露于二氧化氮（NO2），颗粒物小于2.5 um（PM2.5）和小于10 um（ PM10）的空气动力学直径。针对大气压力，温度，湿度和国定假日对模型进行了调整。获得了从0到15的滞后的赔率，以及获得访问前7天（Iag07）的平均值。次要分析仅针对住院儿童。结果：2333名儿童因毛细支气管炎而向PER汇报。发现滞后0，滞后1，滞后3和Iag07与PM2.5和PM10都有关联。仅考虑到结局更为严重的儿童导致住院治疗，这种关联在统计学上具有显着意义，直到第5位和Iag07为止。从滞后5到滞后13，发现了NO2对PER入院和住院的主要影响。结论：PM和NO2与毛细支气管炎的PER入院有关。婴儿暴露于空气污染下会损害呼吸道粘膜，从而促进病毒感染并加剧症状。

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