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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Assessing lower airway exposure to monodispersed micron-sized fluorescent particles by an in-vitro respiratory system
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Assessing lower airway exposure to monodispersed micron-sized fluorescent particles by an in-vitro respiratory system

机译：通过体外呼吸系统评估较低的气道暴露于单分散的微米级荧光颗粒的程度

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Millions of people died of COPD and pneumoconiosis per year. Lower airway exposure to micron-sized particles is considered as the most threatening factors. Many efforts have been dedicated to quantify the concentration of particles in human breathing zone or inside the human respiratory system. But the discrepancy between different diameter particles from breathing zone into lower airway is still unknown. That's exactly an important information for assessing the harm of particles to human health. We developed an in-vitro respiratory system with a CT-imaging-based airway replica and a conjunct breathing machine. The airway replica contains face, nasal cavity, throat, trachea, the first five stages of bronchi and lung volumes. It is 3D-printed based on the CT scanning from a healthy volunteer. Monodispersed fluorescent particles with the aerodynamic diameters dae 0.6-5 pm were generated by TSI VOAG 3450® and monitored by TSI APS 3321®. The lower airway exposure was measured as the total accumulative particles that enters the lung volumes during the sampling period. SKC BioSampler® was used for collecting the fluorescent particles in the lung volumes. The quantity of the fluorescent strength was measured by Horiba Fluoro Max-4®. Particle concentration of breathing zone was evaluated through numerical simulation based on the experimental set-up. Results shown more than 30 % of 0.6 pm, 1 pm and 2 pm particles in human breathing zone can reach lower airway. The percentage becomes much smaller for larger particles. (20.4 ± 8.2)% for 3 pm particles and (5.1 ± 0.2)% for 5 pm particles are able to reach the lower airway. Our results are close to but still different with the classic ICRP66 model, which is based on anatomy replica measurements. This low-cost in-vitro system inspires a new method to access personal exposure to indoor particulate contaminants, especially for people with respiratory preconditions.
机译：每年有数百万人死于COPD和尘肺病。降低呼吸道对微米级颗粒的接触被认为是最危险的因素。已经进行了许多努力来量化人类呼吸区域或人类呼吸系统内部的颗粒浓度。但是从呼吸区到下呼吸道的不同直径颗粒之间的差异仍然未知。这正是评估颗粒物对人体健康危害的重要信息。我们开发了一种体外呼吸系统，该系统具有基于CT成像的气道复制品和联合呼吸机。气道复制品包含面部，鼻腔，喉咙，气管，支气管和肺部容积的前五个阶段。它是根据来自健康志愿者的CT扫描进行3D打印的。 TSI VOAG3450®产生空气动力学直径dae为0.6-5 pm的单分散荧光颗粒，TSI APS3321®对其进行监控。较低的呼吸道暴露被测量为在采样期间进入肺部容积的总累积颗粒。 SKCBioSampler®用于收集肺部容积中的荧光颗粒。荧光强度的量通过Horiba Fluoro Max-4进行测量。在实验设置的基础上，通过数值模拟对呼吸区的颗粒浓度进行了评估。结果显示，人的呼吸区域中0.6 pm，1 pm和2 pm的颗粒中有30％以上可以到达下呼吸道。对于较大的颗粒，该百分比变得小得多。 3 pm颗粒的（20.4±8.2）％和5 pm颗粒的（5.1±0.2）％可以到达下呼吸道。我们的结果与基于解剖复制品测量的经典ICRP66模型接近，但仍然有所不同。这种低成本的体外系统激发了一种新方法，使个人可以接触室内颗粒污染物，特别是对于有呼吸先决条件的人。

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