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Analysis of Energy Deposition in Hadrontherapy Using Monte Carlo Simulation Toolkit GEANT4

机译:使用Monte Carlo模拟工具包GEANT4分析强子疗法中的能量沉积

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This work focuses on one of the most important stages of hadrontherapy treatment planning. The simulation is performed using Monte Carlo (MC) Treatment Planning toolkit GEANT4 which is considered as the most accurate three-dimensional (3-D) dose calculation algorithm for studying Bragg peaks in tissue-equivalent material and dosimetric validation. In hadrontherapy, the study of a significant difference in the position of the Bragg peak is important to get realistic results. Proton therapy treatment planning involves a wider and sensitive range of parameters to be evaluated carefully from studying stopping power, linear energy transfer, the energy imparted to secondary particles and their range. The technical parameters from scanning, modification, accuracy and time also need to be assessed precisely as these vary from patient to patient depending on the health condition. All these parameters vary with Monte Carlo inputs and a slight variation in input generates different results, where, hadrontherapy treatment demands high precision. In this preliminary work, we studied one of the crucial factors 'Step limit' which shows the maximum 'step size' and limited by the accuracy and time factor of simulation. The simulation in GEANT4 is executed by activating suitable Physics Model 'QGSP_BIC with default electromagnetic physics model em_option_3 implemented in Geant4 taking proton as an incident particle with energies 70, 100 and 130 MeV. For simulation, the implemented step size is 0.5 and 0.05 mm step size. The step size value 0.05 mm is found superlative for simulation taking into account simulation time and accuracy.
机译:这项工作的重点是强子疗法治疗计划的最重要阶段之一。使用Monte Carlo(MC)治疗计划工具包GEANT4进行模拟,GEANT4被认为是研究组织等效材料中布拉格峰和剂量学验证的最精确的三维(3-D)剂量计算算法。在强子疗法中,对布拉格峰位置的显着差异的研究对于获得实际结果很重要。质子疗法的治疗计划涉及广泛而敏感的参数范围,需要通过研究停止功率,线性能量传递,传递给次级粒子的能量及其范围来仔细评估。还需要精确评估来自扫描,修改,准确性和时间的技术参数,因为这些参数根据患者的健康状况而有所不同。所有这些参数随蒙特卡洛输入的不同而变化,输入的微小变化会产生不同的结果,其中强子疗法的治疗需要高精度。在这项初步工作中,我们研究了关键因素“步长限制”,它显示了最大的“步长”,并且受仿真的准确性和时间因素的限制。通过激活适当的物理模型'QGSP_BIC,使用在Geant4中实现的默认电磁物理模型em_option_3来执行GEANT4中的模拟,该模型以质子作为入射粒子,能量为70、100和130 MeV。为了进行仿真,实现的步长为0.5和0.05 mm步长。考虑到仿真时间和精度,发现步长值0.05 mm对于仿真来说是最高的。

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