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Reconstruction of Dementia Gene Network Using Online Bioinformatics Tools

机译:使用在线生物信息学工具重建痴呆症基因网络

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In this work, the set of genes associated with mental diseases such as dementia was examined and analyzed using previously developed gene ontology annotation tools and databases. The aim of the study is to describe the gene ontologies and molecular mechanisms of dementia based on the analysis of the related human gene set using available bioinformatics databases, annotation and recent publications. Dementia is a chronic, general, usually irreversible decrease in cognitive function that affects all aspects of cognitive activity. The enriched gene ontology categories for dementia genes are regulation of neuronal death and cell death, cellular components organization, and cognition. A high connectivity of genes and their products was discovered when studying the structure of the gene network.
机译:在这项工作中,使用先前开发的基因本体注释工具和数据库检查和分析了与精神疾病(如痴呆)相关的一组基因。这项研究的目的是在使用相关的生物信息学数据库,注释和最新出版物对相关人类基因组进行分析的基础上,描述痴呆症的基因本体论和分子机制。痴呆症是一种慢性的,普遍的,通常不可逆的认知功能下降,会影响认知活动的各个方面。痴呆症基因的丰富基因本体论类别是神经元死亡和细胞死亡的调控,细胞成分的组织和认知。在研究基因网络的结构时,发现了基因及其产物的高度连通性。

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