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首页> 外文会议>IEEE International Ultrasonics Symposium >In Vivo Demonstration of Single Transducer Harmonic Motion Imaging (ST-HMI) in a Breast Cancer Mouse Model and Breast Cancer Patients
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In Vivo Demonstration of Single Transducer Harmonic Motion Imaging (ST-HMI) in a Breast Cancer Mouse Model and Breast Cancer Patients

机译：在乳腺癌小鼠模型和乳腺癌患者体内的单换能器谐波运动成像（ST-HMI）的体内演示

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Harmonic motion imaging (HMI) interrogates the mechanical properties of tissues by simultaneously generating and tracking amplitude-modulated (AM) force-induced motion using focused ultrasound and imaging transducers, respectively. The main advantages of HMI are that motion at oscillation frequency can be easily filtered from different motion artifacts. However, the current configuration of two separate transducers renders the HMI system highly complex. The objective of this study is to develop a single transducer HMI (ST-HMI) and test its feasibility of generating and mapping of harmonic motion using a linear array transducer to facilitate data acquisition. The feasibility of ST-HMI was performed by imaging commercially available two elastic phantoms with two inclusions (N=4), in vivo monitoring of changes in the tumor stiffness of 4T1, orthotropic breast cancer mouse model, and patient with invasive ductal carcinoma (IDC) breast cancer. ST-HMI-derived peak-to-peak displacements (P2PD) successfully contrasted all 4 inclusions with nominal Young's modulus of 8, 10, 40, and 60 kPa and the P2PD ratio of background to inclusion was highly correlated with Young's modulus ratio of inclusion to background with R2 of 0.93. In the mouse study, the median P2PD ratio of the tumor to non-cancerous tissue was 2.0, 3.6, 7.0, and 6.6 at 1, 2, 3, and 4 weeks, respectively, post-injection of the tumor cell. In the clinical study, ST-HMI detected IDC cancer with the P2PD ratio of 1.78. These results indicate that ST-HMI can assess the mechanical properties of tissues via generation and tracking of harmonic motion using a single transducer.
机译：谐波运动成像（HMI）通过分别使用聚焦的超声和成像换能器同时产生和跟踪幅度调制（AM）力引起的运动来询问组织的机械性能。 HMI的主要优点是振荡频率的运动可以容易地从不同的运动伪影过滤。然而，两个单独的换能器的当前配置使HMI系统具有高度复杂的。本研究的目的是开发单个换能器HMI（ST-HMI），并使用线性阵列换能器测试其产生和映射谐波运动的可行性，以便于数据采集。通过使用两个夹杂物（n = 4）进行商业上可用的两个弹性模子来进行ST-HMI的可行性。 在vivo 中 监测4T1，正交乳腺癌小鼠模型的肿瘤僵硬变化，患有侵入性导管癌（IDC）乳腺癌的患者。 ST-HMI衍生的峰 - 峰位移（P2PD）成功地对比所有4个夹杂物，标称杨氏模量为8,10,40和60kPa，并且背景的P2PD与夹杂物的比率与杨氏模量比高度相关与0.93的R2的背景。在小鼠研究中，肿瘤与非癌组织的中值P2PD比例为2.0,3.6,7.0和6.6，分别在1,2,3和4周，肿瘤细胞注射后注射。在临床研究中，ST-HMI检测到具有1.78的P2PD比例的IDC癌症。这些结果表明，ST-HMI可以使用单个换能器通过产生和跟踪谐波运动来评估组织的机械性能。

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