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首页> 外文会议>Society of Photo-Optical Instrumentation Engineers;SPIE Medical Imaging Conference >Spatial integration of radiology and pathology images to characterize breast cancer aggressiveness on pre-surgical MRI
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Spatial integration of radiology and pathology images to characterize breast cancer aggressiveness on pre-surgical MRI

机译：放射学和病理学图像的空间整合，以表征术前MRI对乳腺癌的侵袭性

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The widespread use of screening mammography has resulted in a remarkable rise in the diagnosis of DuctalCarcinoma In Situ (DCIS). A resultant challenge is the early screening of these patients to identify those withconcurrent invasive breast cancer (IBC), as one in five DCIS at biopsy, are upgraded to IBC following surgery.Both x-ray mammography and multi-parametric Magnetic Resonance Imaging (MRI) lack the ability to distin-guish DCIS from IBC reliably. Our robust methodology for 3D alignment of histopathology images and MRIprovides a unique opportunity to spatially map digitized histopathology slides on pre-surgical MRI which isparticularly important in the tumors where DCIS and IBC co-occur as well as for the study of tumor heterogene-ity. In this proof-of-concept study, we developed and evaluated a methodological framework for the 3D spatialalignment of MRI and histopathology slices, using x-ray radiographs as intermediate modality. Our methodologyinvolves (1) the co-registration of 2D x-ray radiographs showing macrosections and corresponding 2D histologyslices, (2) the 3D reconstruction of the ex vivo specimen based on the x-ray images, and aligned histology slices,and (3) the registration of the 3D reconstructed ex vivo specimen with the 3D MRI. The spatially co-registeredMRI and histopathology images may enable the identification of MRI features that distinguish aggressive fromindolent disease on in vivo MRI.
机译：乳腺钼靶筛查的广泛使用已导致导管的诊断显着增加 原位癌（DCIS）。由此带来的挑战是如何对这些患者进行早期筛查，以识别出患有以下疾病的患者： 并发浸润性乳腺癌（IBC）作为活检中DCIS的五分之一，在手术后被升级为IBC。 X射线乳房X线照相术和多参数磁共振成像（MRI）都缺乏分辨能力， 从IBC可靠地检查DCIS。我们用于组织病理学图像和MRI的3D对齐的强大方法 提供了在手术前MRI上空间映射数字化组织病理学幻灯片的独特机会 在同时发生DCIS和IBC的肿瘤以及研究肿瘤异质性方面特别重要 性。在此概念验证研究中，我们开发并评估了3D空间的方法框架 X射线照相作为中间模态，对MRI和组织病理切片进行对齐。我们的方法 涉及（1）二维X射线照片的共同配准，显示宏观截面和相应的二维组织学 切片;（2）基于X射线图像和对齐的组织学切片对离体标本进行3D重建， （3）使用3D MRI对3D重建的离体标本进行配准。在空间上共同注册 MRI和组织病理学图像可以识别MRI特征，从而将侵袭性和 体内MRI表现为惰性疾病。

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