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首页> 外文会议>National Conference on Biomedical Engineering;International Iranian Conference on Biomedical Engineering >Fabrication of nanomaterial-based biosensor for measurement of a microRNA involved in cancer
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Fabrication of nanomaterial-based biosensor for measurement of a microRNA involved in cancer

机译：纳米材料生物传感器的制备测量癌症中涉及的microRNA

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An electrochemical nanobiosensor is described for the voltammetric determination of miRNA-128 as the cancer biomarker. Aptamer chains were immobilized on the surface of a glassy carbon electrode (GCE) via gold nanoparticles/magnetite/reduced graphene oxide (AuNPs/Fe3O4/RGO). FTIR and XRD analysis were used for the characterization of synthesized nanomaterials. Square wave voltammetry (SWV) was used to characterize the modified GCE in a label-free method. The results indicate that the modified working electrode has high selectivity and for miRNA-128 over other biomolecules. The hexacyanoferrate redox system, typically operated at around 0.3 V (vs. Ag/AgCl) was used as an electrochemical probe. The limit of detection (LOD) and linear detection range are 0.05346 fM and 0.1 to 0.9 fM, respectively.
机译：描述了电化学纳米极细管传感器用于伏安法测定miRNA-128作为癌症生物标志物。通过金纳米粒子/磁铁矿/磁铁矿/氧化石墨烯（AUNPS / FE）将适体链固定在玻璃碳电极（GCE）的表面上固定在玻碳电极（GCE）的表面上 3 O. 4 / rgo）。 FTIR和XRD分析用于合成纳米材料的表征。方波伏安法（SWV）用于以无标记方法表征改性的GCE。结果表明，改性的工作电极具有高选择性和MiRNA-128在其他生物分子上具有高的选择性。六氰基甲醛氧化还原系统通常在约0.3V（Vs.Ag / AgCl）约为0.3V（Vs.Ag / AgCl）中作为电化学探针。检测限（LOD）和线性检测范围分别为0.05346 Fm，分别为0.1至0.9 fm。

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